CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	RYR2
Protein Name	RYR2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Protein Family	Ryanodine receptor (TC 1.A.3.1) family
NCBI Gene ID	6262
UniProt ID	Q92736
Enzyme Class	-
Molecular Weight	564567
Protein Length	4967
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Sarcoplasmic reticulum membrane
Function (UniProt annotation)	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Gene Ontology	GO:0001666; GO:0002027; GO:0003143; GO:0003220; GO:0003300; GO:0005219; GO:0005262; GO:0005509; GO:0005513; GO:0005516; GO:0005790; GO:0005886; GO:0006816; GO:0006874; GO:0010460; GO:0010881; GO:0010882; GO:0014701; GO:0014808; GO:0014850; GO:0015278; GO:0016020; GO:0016529; GO:0019722; GO:0019899; GO:0030018; GO:0030509; GO:0030659; GO:0031000; GO:0032991; GO:0033017; GO:0034220; GO:0034236; GO:0034237; GO:0034704; GO:0035584; GO:0035994; GO:0042383; GO:0042802; GO:0043621; GO:0043924; GO:0044325; GO:0048763; GO:0051209; GO:0051284; GO:0051480; GO:0051775; GO:0055117; GO:0060048; GO:0060070; GO:0060402; GO:0070296; GO:0071313; GO:0071872; GO:0072599; GO:0086005; GO:0086029; GO:0086064; GO:0097050; GO:0098735; GO:0098904; GO:0098907; GO:0098910; GO:0098911; GO:1901896; GO:1903779

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S2808	YNRTRRISQTSQVSV	0.753	0.3529	-	-	-	-	14514795	Non high throughput (14514795)	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S2814	ISQTSQVSVDAAHGY	0.345	0.5017	-	-	-	-	-	-	In vivo
CAMK2D (Q13557)	Homo sapiens	S2808	YNRTRRISQTSQVSV	0.753	0.3529	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S2814	ISQTSQVSVDAAHGY	0.345	0.5017	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S2808	YNRTRRISQTSQVSV	0.753	0.3529	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S2808	YNRTRRISQTSQVSV	0.753	0.3529	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04260	Cardiac muscle contraction
hsa04972	Pancreatic secretion
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy

No NCI Nature pathways found