| Gene |
MAP4K1
|
| Protein Name |
M4K1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
11184
|
| UniProt ID |
Q92918
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
91296 |
| Protein Length |
833 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
N/A |
| Function (UniProt annotation) |
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. |
| Gene Ontology |
GO:0000185; GO:0004672; GO:0004674; GO:0005524; GO:0005622; GO:0005737; GO:0006468; GO:0007257; GO:0008283; GO:0008349; GO:0016020; GO:0018105; GO:0023014; GO:0031098; GO:0032147; GO:0046777; GO:1904628 |
