CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PPP1R14A
Protein Name	PP14A_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17)
Protein Family	PP1 inhibitor family
NCBI Gene ID	94274
UniProt ID	Q96A00
Enzyme Class	-
Molecular Weight	16693
Protein Length	147
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Gene Ontology	GO:0004865; GO:0005829; GO:0035690; GO:0042325

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK3 (O43293)	Homo sapiens	S12	RLGKRVLSKLQSPSR	0.103	0.5211	-	-	-	-	11287002	Non high throughput (11287002)	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S130	GLRQPSPSHDGSLSP	0.144	0.8828	-	-	-	-	12604330	Non high throughput (12604330)	In vitro
DAPK3 (O43293)	Homo sapiens	T38	QKRHARVTVKYDRRE	0.852	0.5055	-	-	-	-	-	-	In vitro
PRKD1 (Q15139)	Homo sapiens	T38	QKRHARVTVKYDRRE	0.852	0.5055	-	-	-	-	15003508	Non high throughput (15003508)	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04270	Vascular smooth muscle contraction

No NCI Nature pathways found