CDC25A | M-phase inducer phosphatase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CDC25A
Synonyms
-
Protein Name
M-phase inducer phosphatase 1
UniProt ID
P30304 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000303706
NCBI Gene ID
993
Molecular Weight
59087
Protein Length
524
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1c25)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.3.48; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Localization
Function
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0051087; GO:0004721; GO:0019901; GO:0004725; GO:0051301; GO:0008283; GO:0034644; GO:0000082; GO:0000086; GO:0010971; GO:0110032; GO:0045931; GO:0016579; GO:0051726; GO:0000079; GO:0009314
 
Gene Ontology