CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	TNNI3
Protein Name	TNNI3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Troponin I, cardiac muscle (Cardiac troponin I)
Protein Family	Troponin I family
NCBI Gene ID	7137
UniProt ID	P19429
Enzyme Class	-
Molecular Weight	24008
Protein Length	210
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene Ontology	GO:0001570; GO:0001980; GO:0003009; GO:0003779; GO:0005829; GO:0005861; GO:0006874; GO:0006936; GO:0006940; GO:0007507; GO:0010882; GO:0019855; GO:0019901; GO:0019904; GO:0030017; GO:0030049; GO:0030172; GO:0031014; GO:0032780; GO:0046872; GO:0048306; GO:0051015; GO:0055010; GO:0060047; GO:0060048; GO:0097512; GO:1990584

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S150	TLRRVRISADAMMQA	0.393	0.391	TP	certain	experimental	72 \| 73 \| 55 \|	22493448	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	S23	PAPIRRRSSNYRAYA	0.104	0.6991	-	-	-	-	-	-	in-vivo
PRKAA1 (Q13131)	Homo sapiens	S24	APIRRRSSNYRAYAT	0.016	0.725	-	-	-	-	-	-	in-vivo
PRKD1 (Q15139)	Homo sapiens	S23	PAPIRRRSSNYRAYA	0.104	0.6991	-	-	-	-	-	-	-
PRKD1 (Q15139)	Homo sapiens	S24	APIRRRSSNYRAYAT	0.016	0.725	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S77	GEKGRALSTRCQPLE	0.409	0.5533	-	-	-	-	-	-	-
PHKG2 (P15735)	Homo sapiens	S77	GEKGRALSTRCQPLE	0.409	0.5533	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04260	Cardiac muscle contraction
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy

No NCI Nature pathways found