CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

PIM3

Synonyms

N/A

Protein Name

Serine/threonine-protein kinase pim-3

UniProt ID

Q86V86

Ensembl Gene ID

9606.ENSP00000353824

NCBI Gene ID

415116

Molecular Weight

35,891

Protein Length

326

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm

Function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Gene Ontology

GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006915; GO:0007049; GO:0007346; GO:0043066; GO:0046777; GO:0061179

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Bad (Q61337)	Mus musculus	S112	ETRSRHSSYPAGTEE	-	0.8872	-	-	-	-	-	-	In vivo
Bad (Q61337)	Mus musculus	S136	PFRGRSRSAPPNLWA	-	0.6755	-	-	-	-	-	-	In vivo
Bad (Q61337)	Mus musculus	S155	GRELRRMSDEFEGSF	-	0.5533	-	-	-	-	-	-	In vivo
BAD (Q92934)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	In vivo
IRS1 (P35568)	Homo sapiens	S1101	GCRRRHSSETFSSTP	0.923	0.8162	-	-	-	-	-	-	in-vivo
Notch1 (Q01705)	Mus musculus	S2152	GKKARKPSTKGLACG	-	0.7209	-	-	-	-	-	-	in-vitro
BAD (Q92934)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	-	-	-
BAD (Q92934)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	-
N/A (B4DZQ9)	Homo sapiens	S75	EIRSRHSSYPAGTED	-	0.8596	-	-	-	-	-	-	-
N/A (B4DZQ9)	Homo sapiens	S99	PFRGRSRSAPPNLWA	-	0.8421	-	-	-	-	-	-	-
N/A (B4DZQ9)	Homo sapiens	S118	GRELRRMSDEFVDSF	-	0.6531	-	-	-	-	-	-	-
NOTCH1 (P46531)	Homo sapiens	S2162	GKKVRKPSSKGLACG	0.565	0.6375	-	-	-	-	-	-	-
CDKN1B (P46527)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	-	-	-	-	-	-	-
CDKN1B (P46527)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found