CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CDKN1B
Protein Name	CDN1B_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Protein Family	CDI family
NCBI Gene ID	1027
UniProt ID	P46527
Enzyme Class	-
Molecular Weight	22073
Protein Length	198
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus. Cytoplasm. Endosome
Function (UniProt annotation)	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Gene Ontology	GO:0000079; GO:0000082; GO:0001666; GO:0001890; GO:0004693; GO:0004860; GO:0004861; GO:0005072; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006813; GO:0006977; GO:0007050; GO:0007096; GO:0007219; GO:0007605; GO:0008284; GO:0008285; GO:0009749; GO:0010942; GO:0019901; GO:0019903; GO:0030308; GO:0030332; GO:0030544; GO:0031116; GO:0031464; GO:0032355; GO:0032991; GO:0033673; GO:0042326; GO:0042493; GO:0043066; GO:0043200; GO:0043231; GO:0043434; GO:0044877; GO:0045732; GO:0045736; GO:0045737; GO:0045786; GO:0045787; GO:0045892; GO:0045930; GO:0046686; GO:0048102; GO:0048839; GO:0051087; GO:0051271; GO:0060770; GO:0071236; GO:0071285; GO:0071407; GO:0071850; GO:1902746; GO:1904030; GO:1904706

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	TP	certain	experimental	23 \| 73 \| 55 \|	14504289	-	-
PRKAA1 (Q13131)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	TP	certain	experimental	72 \| 73 \| 8 \| 55 \| 273 \| 107 \|	17237771	-	In vitro
CAMK1 (Q14012)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	TP	certain	experimental	3 \| 55 \| 148 \| 73 \| 9 \| 36 \|	23707388	-	-
CAMK1 (Q14012)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	TP	certain	experimental	55 \| 72 \| 73 \| 36 \| 3 \| 9 \|	23707388	-	-
PIM1 (P11309-2)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	TP	certain	experimental	23 \| 73 \| 72 \| 148 \| 9 \|	18593906	-	-
PIM1 (P11309-2)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	TP	certain	experimental	23 \| 73 \| 72 \| 148 \| 9 \|	18593906	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S10	NVRVSNGSPSLERMD	0.644	0.7505	-	-	-	-	-	-	In vitro
PIM1 (P11309)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	-	-	-	-	-	-	In vitro and in vivo
PIM1 (P11309)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	-	-	In vitro and in vivo
RPS6KA2 (Q15349)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	14504289	Non high throughput (14504289)	-
RPS6KA1 (Q15418)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	-	-	-
PIM3 (Q86V86)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	-	-	-	-	-	-	-
PIM3 (Q86V86)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	-	-	-
PIM2 (Q9P1W9)	Homo sapiens	T157	GIRKRPATDDSSTQN	0.142	0.8279	-	-	-	-	-	-	-
PIM2 (Q9P1W9)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	-	-	-
CAMK1 (Q14012)	Homo sapiens	T170	QNKRANRTEENVSDG	0.565	0.9381	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04012	ErbB signaling pathway
hsa04110	Cell cycle
hsa05162	Measles
hsa05200	Pathways in cancer
hsa05215	Prostate cancer
hsa05220	Chronic myeloid leukemia
hsa05222	Small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
avb3_integrin_pathway	Integrins in angiogenesis
foxopathway	FoxO family signaling
hnf3apathway	FOXA1 transcription factor network
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
telomerasepathway	Regulation of Telomerase