CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	BAD
Protein Name	BAD_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
Protein Family	Bcl-2 family
NCBI Gene ID	572
UniProt ID	Q92934
Enzyme Class	-
Molecular Weight	18392
Protein Length	168
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Mitochondrion outer membrane. Cytoplasm
Function (UniProt annotation)	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Gene Ontology	GO:0001836; GO:0001844; GO:0005543; GO:0005739; GO:0005741; GO:0005829; GO:0006007; GO:0006915; GO:0006919; GO:0007283; GO:0008289; GO:0008625; GO:0008630; GO:0008656; GO:0009749; GO:0010508; GO:0010918; GO:0019050; GO:0019221; GO:0019901; GO:0019903; GO:0021987; GO:0030346; GO:0032024; GO:0032355; GO:0032570; GO:0033133; GO:0033574; GO:0034201; GO:0035774; GO:0042542; GO:0042593; GO:0043065; GO:0043200; GO:0043280; GO:0043422; GO:0044342; GO:0045471; GO:0045579; GO:0045582; GO:0045862; GO:0046031; GO:0046034; GO:0046902; GO:0046931; GO:0046982; GO:0050679; GO:0051384; GO:0051592; GO:0060139; GO:0060154; GO:0071247; GO:0071260; GO:0071316; GO:0071396; GO:0071456; GO:0071889; GO:0090200; GO:0097191; GO:0097192; GO:0097193; GO:0097202; GO:1900740; GO:1901216; GO:1902220; GO:1904710; GO:2000078; GO:2001244

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	In vitro
PRKD1 (Q15139)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	-	-	In vitro and in vivo
PRKD1 (Q15139)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	In vitro and in vivo
PRKD1 (Q15139)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	In vitro
RPS6KA2 (Q15349)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	10558990	Non high throughput (10558990)	-
RPS6KA1 (Q15418)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	10837486	Non high throughput (10837486)	-
RPS6KA1 (Q15418)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	10837486	Non high throughput (10837486)	In vitro and in vivo
PIM3 (Q86V86)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	In vivo
PIM1 (P11309)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	in-vivo
PIM1 (P11309)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	-	-	-
PIM1 (P11309)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S134	KGLPRPKSAGTATQM	0.882	0.8343	-	-	-	-	-	-	-
PIM3 (Q86V86)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	-	-	-
PIM3 (Q86V86)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	-
PIM2 (Q9P1W9)	Homo sapiens	S118	GRELRRMSDEFVDSF	0.787	0.5854	-	-	-	-	-	-	-
PIM2 (Q9P1W9)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	-	-	-
PIM2 (Q9P1W9)	Homo sapiens	S99	PFRGRSRSAPPNLWA	0.9	0.805	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S134	KGLPRPKSAGTATQM	0.882	0.8343	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04012	ErbB signaling pathway
hsa04210	Apoptosis
hsa04370	VEGF signaling pathway
hsa04510	Focal adhesion
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05145	Toxoplasmosis
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
alphasynuclein_pathway	Alpha-synuclein signaling
ceramidepathway	Ceramide signaling pathway
igf1_pathway	IGF1 pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
met_pathway	Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)
nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
p75ntrpathway	p75(NTR)-mediated signaling
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma