CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

CAMK1G

Synonyms

CLICK3 VWS1

Protein Name

Calcium/calmodulin-dependent protein kinase type 1G

UniProt ID

Q96NX5

Ensembl Gene ID

9606.ENSP00000009105

NCBI Gene ID

57172

Molecular Weight

53,087

Protein Length

476

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2jam)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Golgi apparatus membrane Peripheral membrane protein Cell membrane Peripheral membrane protein

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).

Gene Ontology

GO:0000139; GO:0004683; GO:0005516; GO:0005524; GO:0005886; GO:0005954; GO:0043005

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
EIF4G3 (O43432)	Homo sapiens	S1156	NTFMRGGSSKDLLDN	0.511	0.7547	TP	certain	experimental	72 \| 73 \| 8 \| 55 \|	22514323	-	-
NUMB (P49757-9)	Homo sapiens	S22	YVPEASRPHQWQTDE	-	-	-	-	-	10 \|	-	-	-
CREB1 (P16220)	Homo sapiens	S133	EILSRRPSYRKILND	-	0.5055	-	-	-	-	-	-	-
EP300 (Q09472)	Homo sapiens	S89	SELLRSGSSPNLNMG	0.391	0.6948	-	-	-	-	-	-	-
ACACA (Q13085)	Homo sapiens	S25	RFIIGSVSEDNSEDE	0	0.4979	-	-	-	-	-	-	-
SYN1 (P17600)	Homo sapiens	S9	NYLRRRLSDSNFMAN	0.991	0.562	-	-	-	-	-	-	-
CAMK1 (Q14012)	Homo sapiens	T177	DPGSVLSTACGTPGY	0.726	0.3286	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found