CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	MYL12B
Protein Name	ML12B_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Protein Family	N/A
NCBI Gene ID	10391010627
UniProt ID	O14950
Enzyme Class	-
Molecular Weight	19779
Protein Length	172
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Gene Ontology	GO:0001725; GO:0005509; GO:0005829; GO:0005903; GO:0006936; GO:0008360; GO:0016460; GO:0030018; GO:0032036; GO:0045177; GO:0070062; GO:0099738

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MYLK (Q15746)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.891	0.5665	TP	certain	experimental	73 \| 8 \|	11942626	-	In vitro and in vivo
MYLK (Q15746)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.589	0.5382	TP	certain	experimental	73 \| 8 \|	11942626	-	In vitro
Dapk1 (Q80YE7)	Mus musculus	S20	KRPQRATSNVFAMFD	0.891	0.5665	TP	certain	-	72 \| 8 \| 73 \|	11485996	-	-
Dapk1 (Q80YE7)	Mus musculus	T19	KKRPQRATSNVFAMF	0.589	0.5382	TP	certain	-	72 \| 8 \| 73 \|	11485996	-	-
MYLK2 (Q9H1R3)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.891	0.5665	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYLK2 (Q9H1R3)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.589	0.5382	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
DAPK3 (O43293)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.589	0.5382	TP	certain	-	55 \| 74 \|	15002035	-	-
DAPK3 (O43293)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.891	0.5665	-	-	-	-	-	-	In vitro and in vivo
DAPK1 (P53355)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.891	0.5665	-	-	-	-	-	-	In vitro
DAPK1 (P53355)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.589	0.5382	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04510	Focal adhesion
hsa04530	Tight junction
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton

No NCI Nature pathways found