CaMKipedia | Result

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Sequence Viewer

Gene

MYLK2

Synonyms

N/A

Protein Name

Myosin light chain kinase 2, skeletal/cardiac muscle

UniProt ID

Q9H1R3

Ensembl Gene ID

9606.ENSP00000365152

NCBI Gene ID

85366

Molecular Weight

64,685

Protein Length

596

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2LV6)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.18 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

Localization

Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.

Function

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.

Gene Ontology

GO:0004683; GO:0004687; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006941; GO:0007274; GO:0010628; GO:0014816; GO:0018107; GO:0030017; GO:0032027; GO:0032971; GO:0035914; GO:0046777; GO:0055008; GO:0060048

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MYL9 (P24844)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.877	0.5665	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYL12A (P19105)	Homo sapiens	S19	KRPQRATSNVFAMFD	0.788	0.5665	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYL12B (O14950)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.891	0.5665	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYL9 (P24844)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.572	0.5342	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYL12A (P19105)	Homo sapiens	T18	KKRPQRATSNVFAMF	0.591	0.5456	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MYL12B (O14950)	Homo sapiens	T19	KKRPQRATSNVFAMF	0.589	0.5382	TP	certain	experimental	62 \| 72 \| 74 \|	11942626	-	-
MEF2C (Q06413)	Homo sapiens	T80	NEPHESRTNSDIVET	0.797	0.6661	-	-	-	-	-	-	in-vivo

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04510	Focal adhesion
hsa04810	Regulation of actin cytoskeleton
hsa04971	Gastric acid secretion

No NCI Nature pathways found