CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PPP1R12A
Protein Name	MYPT1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Protein Family	N/A
NCBI Gene ID	4659
UniProt ID	O14974
Enzyme Class	-
Molecular Weight	115281
Protein Length	1030
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Gene Ontology	GO:0000278; GO:0000776; GO:0004857; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007098; GO:0007165; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0071889; GO:0072357

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
NUAK1 (O60285)	Homo sapiens	S445	LGLRKTGSYGALAEI	0.674	0.5017	TP	certain	experimental	135 \| 30 \| 9 \|	20354225	-	-
NUAK1 (O60285)	Homo sapiens	S472	AGVTRSASSPRLSSS	0.669	0.7369	TP	certain	experimental	135 \| 30 \| 9 \|	20354225	-	-
NUAK1 (O60285)	Homo sapiens	S910	SLLGRSGSYSYLEER	0.14	0.5055	TP	likely	experimental	135 \| 30 \| 9 \|	20354225	-	-
DAPK3 (O43293)	Homo sapiens	T637	VTIPVAPTVVNAAAS	0.581	0.7629	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04270	Vascular smooth muscle contraction
hsa04510	Focal adhesion
hsa04720	Long-term potentiation
hsa04810	Regulation of actin cytoskeleton

No NCI Nature pathways found