CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	RPS6KA5
Protein Name	KS6A5_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Protein Family	Protein kinase superfamily
NCBI Gene ID	9252
UniProt ID	O75582
Enzyme Class	2.7.11.1
Molecular Weight	89865
Protein Length	802
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
Function (UniProt annotation)	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).
Gene Ontology	GO:0000287; GO:0001818; GO:0002223; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0006468; GO:0006954; GO:0007173; GO:0007411; GO:0016572; GO:0032793; GO:0033129; GO:0035066; GO:0035556; GO:0043987; GO:0043988; GO:0043990; GO:0045892; GO:0045944; GO:0051092; GO:0070498

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA5 (O75582)	Homo sapiens	S212	DETERAYSFCGTIEY	0.818	0.1184	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S376	EKLFQGYSFVAPSIL	0.904	0.1206	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S381	GYSFVAPSILFKRNA	0.85	0.0341	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S750	RRKMKKTSTSTETRS	0.571	0.7369	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S752	KMKKTSTSTETRSSS	0.271	0.8313	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S758	TSTETRSSSSESSHS	0.482	0.8279	-	-	-	-	15568999	Non high throughput (15568999)	In vitro and in vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05219	Bladder cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
lpa4_pathway	LPA4-mediated signaling events
mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta