PID pathway - Trk receptor signaling mediated by the MAPK pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| SRF \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| AGO2 \| PARN \| CRYAB \| Creb1 \| CREB1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| HNRNPA0 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| IRS1 \| TSC2 \| Tsc2 \| GSK3B \| ETV1 \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| NFKBIB \| PPP1R3A \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| ESR2 \| BAD \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CEBPB \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \| HMGN1 \| TH \| HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \| H3F3A; H3F3B \| RELA \| Rela \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ad \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
CREB1	Cyclic AMP-responsive element-binding protein 1	P16220	MAPKAPK2 \| TSSK4 \| CAMK1D \| RPS6KA4 \| PRKD1 \| CAMK4 \| RPS6KA5 \| RPS6KA3 \| RPS6KA2 \| RPS6KA1 \| CAMK2D \| CAMK1 \| CAMK1G \| CAMK2A \| CAMK2B \| CAMK2G \|
ELK1	ETS domain-containing protein Elk-1	P19419	RPS6KA5 \|
FOS	Proto-oncogene c-Fos	P01100	RPS6KA2 \| RPS6KA1 \|
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	MAPKAPK2 \|
MEF2C	Myocyte-specific enhancer factor 2C	Q06413	RPS6KA2 \| MYLK2 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	RPS6KA1 \| MAPKAPK2 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \|
SRF	Serum response factor	P11831	MAPKAPK2 \| CAMK4 \| RPS6KA5 \| CAMK2A \|