CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	HSPB1
Protein Name	HSPB1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27)
Protein Family	Small heat shock protein (HSP20) family
NCBI Gene ID	3315
UniProt ID	P04792
Enzyme Class	-
Molecular Weight	22783
Protein Length	205
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).
Gene Ontology	GO:0000502; GO:0001895; GO:0001932; GO:0003723; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0042803; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044183; GO:0045766; GO:0061077; GO:0070062; GO:0070527; GO:0099641; GO:1902176; GO:1904115; GO:2001028

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S15	FSLLRGPSWDPFRDW	0.564	0.1373	TP	certain	experimental	18 \| 72 \| 62 \| 50 \|	10383393	-	-
MAPKAPK2 (P49137)	Homo sapiens	S78	PAYSRALSRQLSSGV	0.601	0.3356	TP	certain	experimental	18 \| 72 \| 62 \| 50 \|	10383393	-	-
MAPKAPK2 (P49137)	Homo sapiens	S82	RALSRQLSSGVSEIR	0.622	0.3807	TP	certain	experimental	18 \| 72 \| 62 \| 50 \|	10383393	-	-
PRKD1 (Q15139)	Homo sapiens	S82	RALSRQLSSGVSEIR	0.622	0.3807	TP	certain	experimental	55 \| 72 \| 9 \| 73 \|	15728188	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S78	PAYSRALSRQLSSGV	0.601	0.3356	TP	certain	experimental	72 \| 73 \| 23 \| 55 \|	19166925	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S82	RALSRQLSSGVSEIR	0.622	0.3807	TP	certain	experimental	72 \| 73 \| 23 \| 55 \|	19166925	-	-
MAPKAPK3 (Q16644)	Homo sapiens	S15	FSLLRGPSWDPFRDW	0.564	0.1373	-	-	-	-	-	-	-
MAPKAPK3 (Q16644)	Homo sapiens	S78	PAYSRALSRQLSSGV	0.601	0.3356	-	-	-	-	-	-	-
MAPKAPK3 (Q16644)	Homo sapiens	S82	RALSRQLSSGVSEIR	0.622	0.3807	-	-	-	-	-	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S15	FSLLRGPSWDPFRDW	0.564	0.1373	-	-	-	-	-	-	-
CAMK1 (Q14012)	Homo sapiens	S15	FSLLRGPSWDPFRDW	0.564	0.1373	-	-	-	-	-	-	-
CAMK4 (Q16566)	Homo sapiens	S15	FSLLRGPSWDPFRDW	0.564	0.1373	-	-	-	-	-	-	-
CAMK4 (Q16566)	Homo sapiens	S82	RALSRQLSSGVSEIR	0.622	0.3807	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04370	VEGF signaling pathway
hsa05146	Amoebiasis

NCI Nature PID Pathways

Pathway ID	Pathway Name
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2