| Gene |
EIF4E
|
| Protein Name |
IF4E_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) |
| Protein Family |
Eukaryotic initiation factor 4E family |
| NCBI Gene ID |
1977
|
| UniProt ID |
P06730
|
| Enzyme Class |
- |
| Molecular Weight |
25097 |
| Protein Length |
217 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, P-body |
| Function (UniProt annotation) |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Gene Ontology |
GO:0000082; GO:0000339; GO:0000340; GO:0000932; GO:0001662; GO:0003723; GO:0003743; GO:0005737; GO:0005829; GO:0005845; GO:0006405; GO:0006406; GO:0006413; GO:0006417; GO:0010494; GO:0016032; GO:0016281; GO:0016442; GO:0017148; GO:0019827; GO:0019899; GO:0030324; GO:0031370; GO:0033391; GO:0036464; GO:0045182; GO:0045665; GO:0045931; GO:0048471; GO:0070062; GO:0070491; GO:0071549; GO:0098978; GO:0099524; GO:0099578 |
