CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	MAPT
Protein Name	TAU_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Protein Family	N/A
NCBI Gene ID	4137
UniProt ID	P10636
Enzyme Class	-
Molecular Weight	78928
Protein Length	758
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm, cytosol Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Function (UniProt annotation)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Gene Ontology	GO:0000226; GO:0001774; GO:0003677; GO:0003680; GO:0003690; GO:0003697; GO:0003723; GO:0003779; GO:0005576; GO:0005622; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005874; GO:0005886; GO:0006475; GO:0006919; GO:0007267; GO:0007416; GO:0007611; GO:0007613; GO:0008017; GO:0010288; GO:0010506; GO:0010629; GO:0010917; GO:0015630; GO:0016072; GO:0016607; GO:0017124; GO:0019896; GO:0019899; GO:0019901; GO:0021954; GO:0030424; GO:0030425; GO:0030426; GO:0030673; GO:0030674; GO:0031110; GO:0031113; GO:0031116; GO:0031122; GO:0031175; GO:0032930; GO:0033044; GO:0033673; GO:0034063; GO:0034185; GO:0034399; GO:0034452; GO:0034605; GO:0034614; GO:0035091; GO:0036464; GO:0036477; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0043565; GO:0044297; GO:0044304; GO:0045121; GO:0045298; GO:0045773; GO:0046785; GO:0048018; GO:0048143; GO:0048167; GO:0048312; GO:0048699; GO:0050808; GO:0050848; GO:0051087; GO:0051259; GO:0051260; GO:0051721; GO:0051879; GO:0061564; GO:0070507; GO:0071813; GO:0072386; GO:0090140; GO:0090258; GO:0097386; GO:0097418; GO:0097435; GO:0098930; GO:0099077; GO:0099609; GO:1900034; GO:1900452; GO:1901216; GO:1902474; GO:1902936; GO:1902988; GO:1903748; GO:1903829; GO:1904115; GO:1904428; GO:1905689; GO:1990000; GO:1990090; GO:1990416; GO:2001020

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
SIK1 (P57059)	Homo sapiens	S531	GSRSRTPSLPTPPTR	0.315	0.9744	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S610	NVQSKCGSKDNIKHV	0.623	0.6948	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S622	KHVPGGGSVQIVYKP	0.598	0.4979	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S641	KVTSKCGSLGNIHHK	0.706	0.6043	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S673	RVQSKIGSLDNITHV	0.932	0.4901	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S255	TAAREATSIPGFPAE	0.074	0.9126	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S355	EADLPEPSEKQPAAA	0.268	0.9547	-	-	-	-	-	-	-
PRKAA1 (Q13131)	Homo sapiens	S396	DDKKAKTSTRSSAKT	0.723	0.8894	-	-	-	-	-	-	-
BRSK2 (Q8IWQ3)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
BRSK1 (Q8TDC3)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
MARK4 (Q96L34)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S610	NVQSKCGSKDNIKHV	0.623	0.6948	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S622	KHVPGGGSVQIVYKP	0.598	0.4979	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S641	KVTSKCGSLGNIHHK	0.706	0.6043	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S673	RVQSKIGSLDNITHV	0.932	0.4901	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	T529	TPGSRSRTPSLPTPP	0.375	0.9744	-	-	-	-	-	-	-
BRSK2 (Q8IWQ3)	Homo sapiens	T529	TPGSRSRTPSLPTPP	0.375	0.9744	-	-	-	-	-	-	-
BRSK1 (Q8TDC3)	Homo sapiens	T529	TPGSRSRTPSLPTPP	0.375	0.9744	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa05010	Alzheimer's disease

NCI Nature PID Pathways

Pathway ID	Pathway Name
lysophospholipid_pathway	LPA receptor mediated events
p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta
reelinpathway	Reelin signaling pathway