| Gene |
SRF
|
| Protein Name |
SRF_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serum response factor (SRF) |
| Protein Family |
N/A |
| NCBI Gene ID |
6722
|
| UniProt ID |
P11831
|
| Enzyme Class |
- |
| Molecular Weight |
51593 |
| Protein Length |
508 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. |
| Gene Ontology |
GO:0000790; GO:0000978; GO:0000981; GO:0000982; GO:0001077; GO:0001228; GO:0001569; GO:0001666; GO:0001707; GO:0001764; GO:0001829; GO:0001947; GO:0002011; GO:0002042; GO:0003257; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005737; GO:0006366; GO:0007160; GO:0007275; GO:0007507; GO:0007616; GO:0008134; GO:0008285; GO:0008306; GO:0009636; GO:0009725; GO:0010669; GO:0010735; GO:0010736; GO:0021766; GO:0022028; GO:0030036; GO:0030155; GO:0030168; GO:0030220; GO:0030336; GO:0030878; GO:0031175; GO:0031490; GO:0033561; GO:0034097; GO:0035855; GO:0035912; GO:0042789; GO:0042803; GO:0042826; GO:0043149; GO:0043565; GO:0043589; GO:0044212; GO:0045059; GO:0045214; GO:0045597; GO:0045773; GO:0045944; GO:0045987; GO:0046016; GO:0046716; GO:0048538; GO:0048589; GO:0048666; GO:0048821; GO:0051091; GO:0051150; GO:0051491; GO:0055003; GO:0060055; GO:0060218; GO:0060261; GO:0060292; GO:0060324; GO:0060347; GO:0060425; GO:0060532; GO:0060534; GO:0060947; GO:0061029; GO:0061145; GO:0061629; GO:0070830; GO:0070878; GO:0071333; GO:0090009; GO:0090136; GO:0090398; GO:1900222; GO:1902894; GO:1902895 |
