| Gene |
FLNA
|
| Protein Name |
FLNA_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) |
| Protein Family |
Filamin family |
| NCBI Gene ID |
2316
|
| UniProt ID |
P21333
|
| Enzyme Class |
- |
| Molecular Weight |
280739 |
| Protein Length |
2647 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. |
| Function (UniProt annotation) |
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). |
| Gene Ontology |
GO:0001664; GO:0002576; GO:0003723; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005925; GO:0007195; GO:0008134; GO:0015459; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0021943; GO:0021987; GO:0030018; GO:0030168; GO:0030334; GO:0030863; GO:0031267; GO:0031523; GO:0031532; GO:0031852; GO:0032233; GO:0034329; GO:0034394; GO:0034988; GO:0042177; GO:0042307; GO:0042789; GO:0042803; GO:0043025; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043433; GO:0044319; GO:0044325; GO:0045184; GO:0045296; GO:0046332; GO:0048365; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0060271; GO:0070062; GO:0070527; GO:0071526; GO:0072659; GO:0090307; GO:0097368; GO:0097440; GO:0098794; GO:0098978; GO:1900026; GO:1901381; GO:1902396; GO:1905000; GO:1905031; GO:2000179; GO:2001046; GO:2001224 |
