CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CDC25B
Protein Name	MPIP2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Protein Family	MPI phosphatase family
NCBI Gene ID	994
UniProt ID	P30305
Enzyme Class	3.1.3.48
Molecular Weight	64987
Protein Length	580
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function (UniProt annotation)	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Gene Ontology	GO:0000086; GO:0000278; GO:0000922; GO:0001556; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006468; GO:0007144; GO:0008284; GO:0010971; GO:0019901; GO:0032467; GO:0045860; GO:0045931; GO:0051301; GO:0110032

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MELK (Q14680)	Homo sapiens	S323	QRLFRSPSMPCSVIR	0.939	0.2884	TP	certain	experimental	73 \| 8 \|	12400006	-	In vitro
MAPKAPK2 (P49137)	Homo sapiens	S169	VLRNITNSQAPDGRR	0.502	0.8013	TP	certain	experimental	45 \| 55 \| 72 \|	16861915	-	-
MAPKAPK2 (P49137)	Homo sapiens	S323	QRLFRSPSMPCSVIR	0.939	0.2884	TP	certain	experimental	55 \| 72 \|	16861915	-	-
MAPKAPK2 (P49137)	Homo sapiens	S353	VQNKRRRSVTPPEEQ	0.838	0.8765	TP	certain	experimental	45 \| 55 \| 72 \|	16861915	-	-
MAPKAPK2 (P49137)	Homo sapiens	S375	ARVLRSKSLCHDEIE	0.895	0.3117	TP	certain	experimental	45 \| 55 \| 72 \|	16861915	-	-
MELK (Q14680)	Homo sapiens	S169	VLRNITNSQAPDGRR	0.502	0.8013	TP	certain	experimental	72 \| 73 \| 55 \| 31 \| 143 \|	15908796	-	-
BRSK1 (Q8TDC3-2)	Homo sapiens	S375	ARVLRSKSLCHDEIE	0.895	0.3117	TP	certain	experimental	72 \| 9 \|	15150265	-	-
CHEK1 (O14757)	Homo sapiens	S230	AFAQRPSSAPDLMCL	0.967	0.5533	-	-	-	-	17003105	Non high throughput (17003105)	In vitro and in vivo
CHEK1 (O14757)	Homo sapiens	S563	TFRLKTRSWAGERSR	0.063	0.2783	-	-	-	-	-	-	In vitro
BRSK1 (Q8TDC3)	Homo sapiens	S375	ARVLRSKSLCHDEIE	0.895	0.3117	-	-	-	-	15150265	Non high throughput (15150265)	-
RPS6KA1 (Q15418)	Homo sapiens	S353	VQNKRRRSVTPPEEQ	0.838	0.8765	-	-	-	-	-	-	in-vitro and in-vivo
RPS6KA1 (Q15418)	Homo sapiens	T355	NKRRRSVTPPEEQQE	0.138	0.8828	-	-	-	-	-	-	in-vitro and in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04110	Cell cycle
hsa04110	Cell cycle
hsa04914	Progesterone-mediated oocyte maturation
hsa04914	Progesterone-mediated oocyte maturation

NCI Nature PID Pathways

Pathway ID	Pathway Name
aurora_a_pathway	Aurora A signaling
aurora_a_pathway	Aurora A signaling
foxm1pathway	FOXM1 transcription factor network
foxm1pathway	FOXM1 transcription factor network
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases