CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	TSC2
Protein Name	TSC2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Tuberin (Tuberous sclerosis 2 protein)
Protein Family	N/A
NCBI Gene ID	7249
UniProt ID	P49815
Enzyme Class	-
Molecular Weight	200608
Protein Length	1807
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Function (UniProt annotation)	In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
Gene Ontology	GO:0001843; GO:0005096; GO:0005634; GO:0005737; GO:0005764; GO:0005794; GO:0005829; GO:0006469; GO:0006606; GO:0006897; GO:0007507; GO:0008104; GO:0008285; GO:0014067; GO:0014069; GO:0016020; GO:0016032; GO:0016192; GO:0016239; GO:0019902; GO:0030100; GO:0030178; GO:0031267; GO:0032007; GO:0033596; GO:0042803; GO:0043276; GO:0043491; GO:0046626; GO:0046627; GO:0048009; GO:0048471; GO:0050918; GO:0051056; GO:0051726; GO:0051879; GO:0051898; GO:1901525

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2* (P49137)	Homo sapiens	S1254	TALYKSLSVPAASTA	0.263	0.5807	TP	certain	experimental	74 \| 9 \| 107 \| 45 \|	12582162	-	-
PIM2 (Q9P1W9)	Homo sapiens	S1798	GQRKRLISSVEDFTE	0.406	0.2541	TP	certain	experimental	72 \| 55 \| 9 \| 148 \|	23818547	-	-
RPS6KA1 (Q15418)	Homo sapiens	S1798	GQRKRLISSVEDFTE	0.406	0.2541	-	-	-	-	-	-	In vivo
BRSK2 (Q8IWQ3)	Homo sapiens	S1387	QPLSKSSSSPELQTL	0.645	0.853	-	-	-	-	-	-	in-vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04115	p53 signaling pathway
hsa04150	mTOR signaling pathway
hsa04910	Insulin signaling pathway

NCI Nature PID Pathways

Pathway ID	Pathway Name
mtor_4pathway	mTOR signaling pathway
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt