CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	HDAC7
Protein Name	HDAC7_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)
Protein Family	Histone deacetylase family
NCBI Gene ID	51564
UniProt ID	Q8WUI4
Enzyme Class	3.5.1.98
Molecular Weight	102927
Protein Length	952
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization	Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Function (UniProt annotation)	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Gene Ontology	GO:0000118; GO:0000122; GO:0001570; GO:0003682; GO:0003714; GO:0005080; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007043; GO:0019789; GO:0019901; GO:0032041; GO:0032703; GO:0033613; GO:0045668; GO:0046872; GO:0070491; GO:0071889; GO:0090050; GO:1901223

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MARK2 (Q7KZI7)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	TP	certain	experimental	3 \| 55 \| 73 \| 9 \| 72 \| 143 \|	16980613	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	15623513, 18509061, 18617643	Non high throughput (15623513, 18509061, 18617643)	In vivo
PRKD1 (Q15139)	Homo sapiens	S358	WPLSRTRSEPLPPSA	0.984	0.8085	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S486	RPLSRAQSSPAAPAS	0.983	0.8125	-	-	-	-	-	-	In vivo
MARK3 (P27448)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	-	-	-
CAMK1 (Q14012)	Homo sapiens	S508	SQARVLSSSETPART	0.206	0.662	-	-	-	-	-	-	-
MARK1 (Q9P0L2)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	-	-	-
MARK4 (Q96L34)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

NCI Nature PID Pathways

Pathway ID	Pathway Name
ar_tf_pathway	Regulation of Androgen receptor activity
hdac_classi_pathway	Signaling events mediated by HDAC Class I
hdac_classii_pathway	Signaling events mediated by HDAC Class II
hif1_tfpathway	HIF-1-alpha transcription factor network