CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	TP53
Protein Name	P53_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Protein Family	P53 family
NCBI Gene ID	7157
UniProt ID	P04637
Enzyme Class	-
Molecular Weight	43653
Protein Length	393
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408).; Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; Isoform 9: Cytoplasm.
Function (UniProt annotation)	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Gene Ontology	GO:0000122; GO:0000733; GO:0000790; GO:0000978; GO:0000980; GO:0000981; GO:0001046; GO:0001074; GO:0001085; GO:0001094; GO:0001228; GO:0002020; GO:0002039; GO:0003677; GO:0003682; GO:0003700; GO:0003730; GO:0005507; GO:0005524; GO:0005622; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005759; GO:0005783; GO:0005829; GO:0006284; GO:0006289; GO:0006355; GO:0006914; GO:0006974; GO:0006977; GO:0006978; GO:0006983; GO:0007050; GO:0007265; GO:0007275; GO:0007569; GO:0008104; GO:0008134; GO:0008270; GO:0008283; GO:0008285; GO:0008340; GO:0009299; GO:0010332; GO:0010628; GO:0016032; GO:0016363; GO:0016579; GO:0016605; GO:0019221; GO:0019899; GO:0019901; GO:0019903; GO:0030154; GO:0030308; GO:0030330; GO:0030971; GO:0031497; GO:0031571; GO:0031625; GO:0032461; GO:0032991; GO:0034613; GO:0034644; GO:0035035; GO:0035690; GO:0042149; GO:0042771; GO:0042802; GO:0042826; GO:0042981; GO:0043065; GO:0043066; GO:0043153; GO:0043621; GO:0044212; GO:0045892; GO:0045893; GO:0045899; GO:0045944; GO:0046677; GO:0046827; GO:0046902; GO:0046982; GO:0047485; GO:0048147; GO:0048512; GO:0050731; GO:0051087; GO:0051097; GO:0051262; GO:0051289; GO:0051721; GO:0051974; GO:0065003; GO:0070245; GO:0071158; GO:0071456; GO:0071479; GO:0071480; GO:0072331; GO:0072332; GO:0072717; GO:0090200; GO:0090399; GO:0090403; GO:0097193; GO:0097252; GO:0097718; GO:1900119; GO:1900740; GO:1901796; GO:1902749; GO:1902895; GO:1903800; GO:1990440; GO:1990841; GO:2000379; GO:2001244

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK1 (P53355)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	TP	certain	experimental	73 \| 55 \| 72 \| 74 \| 8 \|	17339337	Non high throughput (17339337)	In vitro and in vivo
MAPKAPK2 (P49137)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	TP	certain	experimental	73 \| 55 \|	11896587	-	In vitro
STK11 (Q15831)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	TP	certain	experimental	74 \| 8 \| 72 \| 73 \| 55 \|	17108107	-	In vitro and in vivo
DAPK1 (P53355)	Homo sapiens	S269	GNLLGRNSFEVRVCA	0.232	0.3599	TP	likely	-	154 \|	20851891	-	-
NUAK1* (O60285)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	TP	certain	experimental	23 \| 72 \| 55 \| 73 \| 9 \|	21317932	-	-
NUAK1* (O60285)	Homo sapiens	S392	FKTEGPDSD______	0.808	0.7755	TP	certain	experimental	23 \| 72 \| 55 \| 73 \| 9 \|	21317932	-	-
MAPKAPK5* (Q8IW41)	Homo sapiens	S37	NVLSPLPSQAMDDLM	0.107	0.7163	TP	certain	experimental	72 \| 30 \| 8 \| 73 \|	17254968	-	-
STK17A* (Q9UEE5)	Homo sapiens	T18	EPPLSQETFSDLWKL	0.691	0.6269	TP	likely	experimental	55 \|	17339337	-	-
CHEK1 (O14757)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	-	-	-	-	-	-	In vitro and in vivo
CHEK1 (O14757)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	-	-	-	-	17339337	Non high throughput (17339337)	In vitro and in vivo
CHEK1 (O14757)	Homo sapiens	S37	NVLSPLPSQAMDDLM	0.107	0.7163	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	S378	SKKGQSTSRHKKLMF	0.826	0.7951	-	-	-	-	-	-	In vitro
DAPK3 (O43293)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	-	-	-	-	17339337	Non high throughput (17339337)	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S366	PGGSRAHSSHLKSKK	0.367	0.9126	-	-	-	-	-	-	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S37	NVLSPLPSQAMDDLM	0.107	0.7163	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S378	SKKGQSTSRHKKLMF	0.826	0.7951	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	-	-	-	-	-	-	In vitro
STK17A (Q9UEE5)	Homo sapiens	S20	PLSQETFSDLWKLLP	0.567	0.6269	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	T18	EPPLSQETFSDLWKL	0.691	0.6269	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	T387	HKKLMFKTEGPDSD_	0.025	0.8375	-	-	-	-	-	-	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	T18	EPPLSQETFSDLWKL	0.691	0.6269	-	-	-	-	-	-	In vitro
DAPK1 (P53355)	Homo sapiens	T18	EPPLSQETFSDLWKL	0.691	0.6269	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	T18	EPPLSQETFSDLWKL	0.691	0.6269	-	-	-	-	-	-	In vitro
SIK1 (P57059)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	-	-	-	-	-	-	-
MELK (Q14680)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	-	-	-	-	-	-	-
PRKAA2 (P54646)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.83	0.7163	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04110	Cell cycle
hsa04115	p53 signaling pathway
hsa04210	Apoptosis
hsa04310	Wnt signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05160	Hepatitis C
hsa05162	Measles
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05217	Basal cell carcinoma
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
aurora_a_pathway	Aurora A signaling
bard1pathway	BARD1 signaling events
hdac_classiii_pathway	Signaling events mediated by HDAC Class III
hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
p75ntrpathway	p75(NTR)-mediated signaling
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt