CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CDKN1A
Protein Name	CDN1A_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Protein Family	CDI family
NCBI Gene ID	1026
UniProt ID	P38936
Enzyme Class	-
Molecular Weight	18119
Protein Length	164
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm. Nucleus.
Function (UniProt annotation)	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Gene Ontology	GO:0000079; GO:0000082; GO:0000086; GO:0000307; GO:0004693; GO:0004860; GO:0004861; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006357; GO:0006367; GO:0006974; GO:0006977; GO:0007050; GO:0007265; GO:0008285; GO:0009636; GO:0010165; GO:0010243; GO:0010942; GO:0016604; GO:0019221; GO:0019901; GO:0019912; GO:0030308; GO:0031100; GO:0031625; GO:0031668; GO:0032991; GO:0034198; GO:0034605; GO:0042326; GO:0042493; GO:0043066; GO:0044877; GO:0045860; GO:0046685; GO:0046872; GO:0048146; GO:0048471; GO:0050821; GO:0051412; GO:0055093; GO:0060574; GO:0070557; GO:0071479; GO:0071493; GO:0090398; GO:0090399; GO:0090400; GO:0097193; GO:1904030; GO:1904706; GO:2000134; GO:2000379

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM2* (Q9P1W9)	Homo sapiens	S146	GRKRRQTSMTDFYHS	0.575	0.725	TP	likely	experimental	73 \| 8 \|	20307683	-	In vitro
PIM1 (P11309)	Homo sapiens	S146	GRKRRQTSMTDFYHS	0.575	0.725	TP	certain	experimental	72 \| 9 \| 55 \|	17855660	-	-
PIM1* (P11309)	Homo sapiens	T145	QGRKRRQTSMTDFYH	0.981	0.7331	TP	certain	experimental	72 \| 9 \| 55 \| 73 \| 39 \|	17855660	-	-
PIM2 (Q9P1W9)	Homo sapiens	T145	QGRKRRQTSMTDFYH	0.981	0.7331	TP	certain	experimental	72 \| 73 \| 9 \| 55 \|	20307683	-	-
Stk11 (Q9WTK7)	Mus musculus	T80	LPKLYLPTGPRRGRD	0.036	0.5665	TP	certain	experimental	72 \| 30 \| 73 \| 55 \| 9 \|	25329316	-	-
DAPK3 (O43293)	Homo sapiens	T145	QGRKRRQTSMTDFYH	0.981	0.7331	-	-	-	-	-	-	In vitro and in vivo
NUAK1 (O60285)	Homo sapiens	S146	GRKRRQTSMTDFYHS	0.575	0.725	-	-	-	-	-	-	-
DAPK1 (P53355)	Homo sapiens	S146	GRKRRQTSMTDFYHS	0.575	0.725	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04012	ErbB signaling pathway
hsa04110	Cell cycle
hsa04115	p53 signaling pathway
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia

NCI Nature PID Pathways

Pathway ID	Pathway Name
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
hdac_classiii_pathway	Signaling events mediated by HDAC Class III
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
prlsignalingeventspathway	Signaling events mediated by PRL
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling