CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	FOXO3
Protein Name	FOXO3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Protein Family	N/A
NCBI Gene ID	2309
UniProt ID	O43524
Enzyme Class	-
Molecular Weight	71277
Protein Length	673
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm, cytosol
Function (UniProt annotation)	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
Gene Ontology	GO:0000122; GO:0000978; GO:0000981; GO:0001221; GO:0001227; GO:0001228; GO:0001542; GO:0001544; GO:0001547; GO:0001556; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0005759; GO:0005829; GO:0006357; GO:0006390; GO:0006417; GO:0007568; GO:0008013; GO:0008134; GO:0008286; GO:0019221; GO:0019901; GO:0030330; GO:0030336; GO:0031490; GO:0031667; GO:0032991; GO:0033209; GO:0034246; GO:0034599; GO:0042593; GO:0043065; GO:0043525; GO:0043565; GO:0045648; GO:0045665; GO:0045893; GO:0045944; GO:0048854; GO:0071333; GO:0071386; GO:0071456; GO:0071548; GO:0090090; GO:0097150; GO:0097192; GO:1901300; GO:1903428; GO:1904646; GO:1990090; GO:1990785; GO:2000177; GO:2000353

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S253	APRRRAVSMDNSNKY	0.762	0.6991	TP	certain	experimental	72 \| 9 \|	18593906	-	In vivo
PIM1 (P11309)	Homo sapiens	T32	QSRPRSCTWPLQRPE	0.886	0.8421	TP	certain	-	72 \| 9 \|	18593906	-	In vivo
PRKAA2* (P54646)	Homo sapiens	S399	DNITLPPSQPSPTGG	0.301	0.7755	U	likely	experimental	72 \| 9 \|	17711846	-	-
PRKAA1* (Q13131)	Homo sapiens	S399	DNITLPPSQPSPTGG	0.301	0.7755	U	likely	experimental	72 \| 9 \|	17711846	-	-
PRKAA2* (P54646)	Homo sapiens	S413	GLMQRSSSFPYTTKG	0.437	0.6322	TP	certain	experimental	72 \| 9 \| 31 \| 55 \| 73 \|	17711846	-	-
PRKAA1* (Q13131)	Homo sapiens	S413	GLMQRSSSFPYTTKG	0.437	0.6322	TP	certain	experimental	72 \| 9 \| 31 \| 55 \| 73 \|	17711846	-	-
PRKAA2* (P54646)	Homo sapiens	S555	RALSNSVSNMGLSES	0.204	0.5493	U	likely	experimental	72 \| 9 \| 31 \|	17711846	-	-
PRKAA1* (Q13131)	Homo sapiens	S555	RALSNSVSNMGLSES	0.204	0.5493	U	likely	experimental	72 \| 9 \| 31 \|	17711846	-	-
PRKAA2* (P54646)	Homo sapiens	S588	QTLSDSLSGSSLYST	0.279	0.5017	U	likely	experimental	72 \| 9 \| 55 \| 73 \|	17711846	-	-
PRKAA1* (Q13131)	Homo sapiens	S588	QTLSDSLSGSSLYST	0.279	0.5017	U	likely	experimental	72 \| 9 \| 55 \| 73 \|	17711846	-	-
PRKAA2* (P54646)	Homo sapiens	S626	SLECDMESIIRSELM	0.672	0.3599	U	likely	experimental	72 \| 9 \| 31 \| 73 \|	17711846	-	-
PRKAA1* (Q13131)	Homo sapiens	S626	SLECDMESIIRSELM	0.672	0.3599	U	likely	experimental	72 \| 9 \| 31 \| 73 \|	17711846	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S215	NSIRHNLSLHSRFMR	0.628	0.4652	TP	certain	experimental	72 \| 9 \| 30 \| 73 \| 53 \|	21329882	-	-
PRKAA2 (P54646)	Homo sapiens	T179	SSPDKRLTLSQIYEW	0.645	0.3872	TP	likely	experimental	72 \| 9 \|	17711846	-	-
PRKAA1 (Q13131)	Homo sapiens	T179	SSPDKRLTLSQIYEW	0.645	0.3872	TP	likely	experimental	72 \| 9 \|	17711846	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S253	APRRRAVSMDNSNKY	0.762	0.6991	-	-	-	-	-	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S555	RALSNSVSNMGLSES	0.204	0.5493	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04062	Chemokine signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05213	Endometrial cancer
hsa05223	Non-small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
foxopathway	FoxO family signaling
hdac_classiii_pathway	Signaling events mediated by HDAC Class III
il2_pi3kpathway	IL2 signaling events mediated by PI3K
insulin_pathway	Insulin Pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pi3kcipathway	Class I PI3K signaling events
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling