PID pathway - Trk receptor signaling mediated by PI3K and PLC-gamma

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	KCND2 \| Nos1 \| PLCB3 \| Nlgn1 \| Ryr2 \| Ryr2 \| Trpv1 \| Syn1 \| EGFR \| NEFL \| TH \| TH \| CACNA1S \| Gja1 \| VIM \| ALOX5 \| MPZ \| MAPT \| Camk2a \| Mylk \| SRF \| CALD1 \| ETS1 \| ETS2 \| Lipe \| Creb1 \| CACNA1C \| CACNA1C \| CD44 \| SYN1 \| Ptpra \| Spr \| Drd3 \| Gria1 \| Gria4 \| FLNA \| Gabrg2 \| Gria1 \| Gjc1 \| MAPT \| NOS1 \| Nos1 \| Vim \| Dlg4 \| Oprm1 \| Ptk2 \| SPR \| HRH1 \| OPRM1 \| SNCA \| GRIA1 \| CDKN1B \| Rph3a \| PLA2G4A \| VIM \| Gabrb1 \| CLCN3 \| RRAD \| PLN \| Pln \| Cdk5r1 \| Il6st \| Mecp2 \| HSF1 \| Grin2b \| Cacna1c \| Cacna1b \| GFPT1 \| GRIN2B \| ESPL1 \| SMAD2 \| Dlg1 \| Kcnd2 \| Tph2 \| RYR2 \| PPP1R14A \| RCHY1 \| CARD11 \| Rims1 \| Pdc \| Lrp4 \| Gabbr1 \| PEA15 \| FBXO43 \| Brsk1 \| SLN \| ITGB1BP1 \| ERBB2 \| ITGB1 \| Chrm4 \| Myog \| TNNT2 \| ITPKA \| PLN \| CHAT \| GLO1 \| Myh9 \| Sln \| Sln \| CAMK2A \| \| NCOR2 \| Itpr2 \| HDAC5 \| Mcu \| Mybpc3 \| TH \| Kif3a \| Slc6a3 \| TCAP \| STMN1 \| Cpeb3 \| KIF3A \| Ppp3ca \| DAGLA \| Abi1 \| NOX5 \| SLC6A4 \| Syngap1 \| KCNQ2 \| Neto2 \| CTNNB1 \| BECN1 \| DLGAP1 \| Wee2 \| ID1 \| Fosb \| NR1H2 \| Psmc5 \| KCNJ11 \| Grm1 \| SLC1A3 \| Trpc6 \| Dpysl2 \| TNNT2 \| DLG1 \| GABRG2 \| PDC \| CLCN3 \| PTPRA \| BCL10 \| KRT18 \| MAPT \| MAPT \| CREB1 \| ATP2A2 \| PTPRA \| PDC \| DRD3 \| DLG1 \| IRF3 \| ABI1 \| HOMER3 \| RYR2 \| TRPV1 \| SYN1 \| NEFL \| CACNA1S \| \| MPZ \| CAMK2A \| CALD1 \| CALD1 \| \| CACNA1C \| CACNA1C \| GRIA4 \| \| GJC1 \| MAPT \| NOS1 \| DLG4 \| PTK2 \| RPH3A \| GABRB1 \| CDK5R1 \| IL6ST \| MECP2 \| CACNA1B \| KCND2 \| TPH2 \| RIMS1 \| LRP4 \| \| PEA15 \| \| GFAP \| \| PDC \| SYNGAP1 \| MCU \| MYBPC3 \| KIF3A \| SLC6A3 \| CPEB3 \| PPP3CA \| FOSB \| \| ATP2A2 \| CEBPB \| CFL2 \| ADCY3 \| QDPR \| GFAP \| ACACA \| RYR1 \| PPP1R9B \| MYLK \| ITGB1BP1 \| CHAT \| BRSK1 \| CHRM4 \| MYF4 \| SLN \| nlgn1 \| GRM1 \| TRPC6 \| \| VPS72 \| \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Q16566	Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Hspb1 \| Camk4 \| MYL12A \| HDAC4 \| RELA \| EP300 \| CREBBP \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	MAPKAPK2 \| SIK2 \| PRKD1 \| CAMKK2 \|
BAD	Bcl2-associated agonist of cell death	Q92934	RPS6KA3 \| PRKD1 \| RPS6KA2 \| RPS6KA1 \| PIM3 \| PIM1 \| CAMK2G \| PIM2 \| CHEK1 \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	CAMK2A \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	CAMK2A \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
CREB1	Cyclic AMP-responsive element-binding protein 1	P16220	MAPKAPK2 \| TSSK4 \| CAMK1D \| RPS6KA4 \| PRKD1 \| CAMK4 \| RPS6KA5 \| RPS6KA3 \| RPS6KA2 \| RPS6KA1 \| CAMK2D \| CAMK1 \| CAMK1G \| CAMK2A \| CAMK2B \| CAMK2G \|
FOXO3	Forkhead box protein O3	O43524	PIM1 \| PRKAA2 \| PRKAA1 \| MAPKAPK5 \|
GSK3B	Glycogen synthase kinase-3 beta	P49841	RPS6KA3 \| RPS6KA1 \| PRKD3 \| STK11 \| CAMK2B \|
SHC1	SHC-transforming protein 1	P29353	Mapkapk2 \| MAPKAPK2 \|
YWHAZ	14-3-3 protein zeta/delta	P63104	MAPKAPK2 \|