CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	ITGB1
Protein Name	ITB1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Protein Family	Integrin beta chain family
NCBI Gene ID	3688
UniProt ID	P05556
Enzyme Class	-
Molecular Weight	88415
Protein Length	798
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
Gene Ontology	GO:0000082; GO:0001618; GO:0001701; GO:0001708; GO:0001726; GO:0001968; GO:0002020; GO:0002042; GO:0003779; GO:0005178; GO:0005737; GO:0005886; GO:0005925; GO:0006909; GO:0006968; GO:0007156; GO:0007159; GO:0007160; GO:0007161; GO:0007229; GO:0008284; GO:0008305; GO:0008354; GO:0008542; GO:0009897; GO:0009986; GO:0010710; GO:0014704; GO:0015026; GO:0016020; GO:0016477; GO:0019221; GO:0021943; GO:0030027; GO:0030030; GO:0030032; GO:0030175; GO:0030183; GO:0030198; GO:0031589; GO:0031594; GO:0031623; GO:0032154; GO:0032587; GO:0033627; GO:0033631; GO:0034113; GO:0034665; GO:0034666; GO:0034667; GO:0034677; GO:0034678; GO:0034680; GO:0034681; GO:0035024; GO:0035748; GO:0042383; GO:0042470; GO:0043065; GO:0043197; GO:0043235; GO:0043236; GO:0043547; GO:0044877; GO:0045121; GO:0045214; GO:0045296; GO:0045596; GO:0045766; GO:0046872; GO:0046982; GO:0048333; GO:0048471; GO:0048675; GO:0048813; GO:0050776; GO:0050804; GO:0050839; GO:0050900; GO:0050901; GO:0051726; GO:0051897; GO:0055007; GO:0055037; GO:0070062; GO:0071404; GO:0071438; GO:0071711; GO:0097386; GO:0098639; GO:0098685; GO:0098978; GO:0099699; GO:1903078; GO:2000273; GO:2000811

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	T788	PIYKSAVTTVVNPKY	0.4	0.3087	-	-	-	-	-	-	In vivo
CAMK2A (Q9UQM7)	Homo sapiens	T789	IYKSAVTTVVNPKYE	0.67	0.2884	-	-	-	-	-	-	In vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04145	Phagosome
hsa04360	Axon guidance
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04514	Cell adhesion molecules (CAMs)
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton
hsa05100	Bacterial invasion of epithelial cells
hsa05130	Pathogenic Escherichia coli infection
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy

NCI Nature PID Pathways

Pathway ID	Pathway Name
a4b1_a4b7_pathway	a4b1 and a4b7 Integrin signaling
a4b1_paxdep_pathway	Paxillin-dependent events mediated by a4b1
a4b1_paxindep_pathway	Paxillin-independent events mediated by a4b1 and a4b7
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
arf6_traffickingpathway	Arf6 trafficking events
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
prlsignalingeventspathway	Signaling events mediated by PRL
reelinpathway	Reelin signaling pathway
syndecan_2_pathway	Syndecan-2-mediated signaling events
syndecan_4_pathway	Syndecan-4-mediated signaling events