| Gene |
NFKBIA
|
| Protein Name |
IKBA_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) |
| Protein Family |
NF-kappa-B inhibitor family |
| NCBI Gene ID |
4792
|
| UniProt ID |
P25963
|
| Enzyme Class |
- |
| Molecular Weight |
35609 |
| Protein Length |
317 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Function (UniProt annotation) |
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Gene Ontology |
GO:0000060; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006915; GO:0007249; GO:0007253; GO:0008134; GO:0008139; GO:0010745; GO:0010875; GO:0010888; GO:0016032; GO:0016579; GO:0019899; GO:0031625; GO:0031663; GO:0032088; GO:0032270; GO:0032495; GO:0033209; GO:0033256; GO:0034142; GO:0035994; GO:0042127; GO:0042802; GO:0042994; GO:0043066; GO:0043330; GO:0043392; GO:0045638; GO:0045746; GO:0045944; GO:0050729; GO:0051059; GO:0070417; GO:0070427; GO:0070431; GO:0070498; GO:1901222 |
