CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Q16566 | Creb1 | Myh9 | HDAC5 | Crebbp | CAMK4 | HNRNPL | STMN1 | SIK2 | PHB2 | CABIN1 | SRF | CREB1 | CAMK2A | Crebbp | LIMK1 | Hspb1 | Camk4 | MYL12A | HDAC4 | RELA | EP300 | CREBBP | Snf1lk2 | NUMB | HSPB1 | NOS1 | ACACA | SYN1 | SNF1LK2 | CAMK1 | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase | P31749 | MAPKAPK2 | SIK2 | PRKD1 | CAMKK2 | |
| CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Q16566 | CAMKK1 | CAMK4 | CAMK1 | |
| CREB1 | Cyclic AMP-responsive element-binding protein 1 | P16220 | MAPKAPK2 | TSSK4 | CAMK1D | RPS6KA4 | PRKD1 | CAMK4 | RPS6KA5 | RPS6KA3 | RPS6KA2 | RPS6KA1 | CAMK2D | CAMK1 | CAMK1G | CAMK2A | CAMK2B | CAMK2G | |
| FOS | Proto-oncogene c-Fos | P01100 | RPS6KA2 | RPS6KA1 | |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | O14920 | PRKAA2 | |
| JUN | Transcription factor AP-1 | P05412 | PRKD1 | |
| MITF | Microphthalmia-associated transcription factor | O75030 | |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEK1 | |
| NFKBIA | NF-kappa-B inhibitor alpha | P25963 | RPS6KA3 | RPS6KA1 | |
| RELA | Transcription factor p65 | Q04206 | PIM1 | CAMK2G | RPS6KA4 | RPS6KA5 | CAMK4 | CHEK1 | |
| SYK | Tyrosine-protein kinase SYK | P43405 | CHEK1 | PRKAA1 | PRKD1 | |