CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CTNNB1
Protein Name	CTNB1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Catenin beta-1 (Beta-catenin)
Protein Family	Beta-catenin family
NCBI Gene ID	1499
UniProt ID	P35222
Enzyme Class	-
Molecular Weight	85497
Protein Length	781
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Gene Ontology	GO:0000122; GO:0000578; GO:0000904; GO:0000922; GO:0001085; GO:0001102; GO:0001569; GO:0001658; GO:0001701; GO:0001702; GO:0001708; GO:0001711; GO:0001764; GO:0001837; GO:0001840; GO:0002052; GO:0002053; GO:0002089; GO:0003266; GO:0003338; GO:0003340; GO:0003682; GO:0003700; GO:0003713; GO:0005622; GO:0005634; GO:0005654; GO:0005667; GO:0005719; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005913; GO:0005916; GO:0005923; GO:0005925; GO:0005938; GO:0007155; GO:0007160; GO:0007223; GO:0007268; GO:0007398; GO:0007403; GO:0008022; GO:0008134; GO:0008285; GO:0009948; GO:0009950; GO:0009954; GO:0010718; GO:0010909; GO:0016020; GO:0016032; GO:0016055; GO:0016323; GO:0016328; GO:0016342; GO:0016525; GO:0016600; GO:0019827; GO:0019899; GO:0019900; GO:0019901; GO:0019903; GO:0021819; GO:0022009; GO:0030018; GO:0030027; GO:0030054; GO:0030316; GO:0030331; GO:0030521; GO:0030539; GO:0030877; GO:0030902; GO:0030997; GO:0031016; GO:0031069; GO:0031528; GO:0031641; GO:0032212; GO:0032331; GO:0032355; GO:0032481; GO:0032991; GO:0032993; GO:0033077; GO:0033234; GO:0034333; GO:0034394; GO:0034750; GO:0035050; GO:0035112; GO:0035115; GO:0035116; GO:0035257; GO:0035315; GO:0035635; GO:0036023; GO:0042129; GO:0042475; GO:0042493; GO:0042733; GO:0042734; GO:0043065; GO:0043066; GO:0043123; GO:0043410; GO:0043525; GO:0044325; GO:0044334; GO:0044336; GO:0045177; GO:0045202; GO:0045211; GO:0045294; GO:0045296; GO:0045453; GO:0045603; GO:0045669; GO:0045671; GO:0045743; GO:0045765; GO:0045892; GO:0045893; GO:0045944; GO:0045976; GO:0046332; GO:0046982; GO:0048096; GO:0048145; GO:0048469; GO:0048471; GO:0048489; GO:0048538; GO:0048599; GO:0048617; GO:0048643; GO:0048660; GO:0048715; GO:0050681; GO:0050767; GO:0050808; GO:0051091; GO:0051145; GO:0051149; GO:0051571; GO:0051884; GO:0051973; GO:0060066; GO:0060070; GO:0060440; GO:0060441; GO:0060479; GO:0060484; GO:0060492; GO:0060742; GO:0060769; GO:0060789; GO:0060828; GO:0060916; GO:0061154; GO:0061198; GO:0061324; GO:0061549; GO:0061550; GO:0070062; GO:0070369; GO:0070411; GO:0070491; GO:0070602; GO:0071363; GO:0071681; GO:0071944; GO:0072033; GO:0072053; GO:0072054; GO:0072079; GO:0072182; GO:0090279; GO:0097091; GO:0097718; GO:0098609; GO:0098685; GO:0098831; GO:0099092; GO:1903204; GO:1904501; GO:1904793; GO:1904798; GO:1904837; GO:1904886; GO:1904888; GO:1904948; GO:1904954; GO:1990138; GO:1990403; GO:1990791; GO:1990907; GO:1990909; GO:2000008; GO:2000017; GO:2000144; GO:2001234

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	T112	EGMQIPSTQFDAAHP	0.535	0.6482	TP	certain	experimental	66 \| 72 \| 135 \| 62 \| 23 \| 73 \| 147 \|	19141652	-	-
PRKD1 (Q15139)	Homo sapiens	T120	QFDAAHPTNVQRLAE	0.721	0.7843	TP	certain	experimental	66 \| 72 \| 135 \| 62 \| 23 \| 73 \| 147 \|	19141652	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S552	QDTQRRTSMGGTQQQ	0.142	0.6755	-	-	-	-	-	-	in-vitro
CAMK2A (Q9UQM7)	Homo sapiens	T472	ICALRHLTSRHQEAE	0.915	0.3774	-	-	-	-	-	-	in-vitro
CAMK2A (Q9UQM7)	Homo sapiens	T332	VNIMRTYTYEKLLWT	0.009	0.0592	-	-	-	-	-	-	in-vitro
PRKAA2 (P54646)	Homo sapiens	S552	QDTQRRTSMGGTQQQ	0.142	0.6755	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04310	Wnt signaling pathway
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04530	Tight junction
hsa04670	Leukocyte transendothelial migration
hsa04916	Melanogenesis
hsa05100	Bacterial invasion of epithelial cells
hsa05130	Pathogenic Escherichia coli infection
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05217	Basal cell carcinoma
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

NCI Nature PID Pathways

Pathway ID	Pathway Name
ar_pathway	Coregulation of Androgen receptor activity
arf6_traffickingpathway	Arf6 trafficking events
foxopathway	FoxO family signaling
met_pathway	Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)
ps1pathway	Presenilin action in Notch and Wnt signaling
tgfbrpathway	TGF-beta receptor signaling
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
wnt_canonical_pathway	Canonical Wnt signaling pathway