CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	PLA2G4A
Protein Name	PA24A_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]
Protein Family	N/A
NCBI Gene ID	5321
UniProt ID	P47712
Enzyme Class	3.1.1.4; 3.1.1.5
Molecular Weight	85239
Protein Length	749
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.; 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Localization	Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
Function (UniProt annotation)	Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Ontology	GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0005634; GO:0005737; GO:0005743; GO:0005783; GO:0005789; GO:0005794; GO:0005811; GO:0005829; GO:0006644; GO:0006654; GO:0006663; GO:0006690; GO:0008970; GO:0019369; GO:0031410; GO:0035965; GO:0036148; GO:0036149; GO:0036150; GO:0036151; GO:0036152; GO:0042127; GO:0046456; GO:0046475; GO:0047498; GO:0050482; GO:0071236; GO:0102567; GO:0102568

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA5 (O75582)	Homo sapiens	S727	RQNPSRCSVSLSNVE	0.781	0.4409	-	-	-	-	-	-	-
MAPKAPK5 (Q8IW41)	Homo sapiens	S727	RQNPSRCSVSLSNVE	0.781	0.4409	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S515	SDFATQDSFDDDELD	0.212	0.4409	-	-	-	-	11479288	Non high throughput (11479288)	-
MKNK1 (Q9BUB5)	Homo sapiens	S727	RQNPSRCSVSLSNVE	0.781	0.4409	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa00564	Glycerophospholipid metabolism
hsa00565	Ether lipid metabolism
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism
hsa00592	alpha-Linolenic acid metabolism
hsa01100	Metabolic pathways
hsa04010	MAPK signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04370	VEGF signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04724	Glutamatergic synapse
hsa04730	Long-term depression
hsa04912	GnRH signaling pathway
hsa04972	Pancreatic secretion
hsa04975	Fat digestion and absorption
hsa05145	Toxoplasmosis

NCI Nature PID Pathways

Pathway ID	Pathway Name
endothelinpathway	Endothelins
fcer1pathway	Fc-epsilon receptor I signaling in mast cells
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta