| Gene |
CREBBP
|
| Protein Name |
CBP_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
CREB-binding protein (EC 2.3.1.48) |
| Protein Family |
N/A |
| NCBI Gene ID |
1387
|
| UniProt ID |
Q92793
|
| Enzyme Class |
2.3.1.48 |
| Molecular Weight |
265351 |
| Protein Length |
2442 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. |
| Localization |
Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. |
| Function (UniProt annotation) |
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). |
| Gene Ontology |
GO:0000122; GO:0000123; GO:0000790; GO:0000987; GO:0001078; GO:0001085; GO:0001102; GO:0001666; GO:0002039; GO:0002223; GO:0003682; GO:0003684; GO:0003700; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0006367; GO:0006473; GO:0007165; GO:0007219; GO:0007221; GO:0008134; GO:0008270; GO:0008589; GO:0016032; GO:0016407; GO:0016573; GO:0016604; GO:0018076; GO:0019216; GO:0030511; GO:0031648; GO:0032481; GO:0034212; GO:0034644; GO:0042592; GO:0042733; GO:0042981; GO:0043426; GO:0045637; GO:0045747; GO:0045893; GO:0045944; GO:0048511; GO:0061418; GO:0065003; GO:1900034; GO:1904837 |
