Help Instruction
- Double clicking on the substrate will redirect to the uniprot entry.
- Clicking in the block having the substrate will zoom into its phophosites
- Clicking the center of the circle will lead to zooming out.
- Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
- The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
- Clicking in the top right corner on the camara icon will download the image.
| Substrate | Organism | PSite | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strap (Q9Z1Z2) | Mus musculus | S188 | NFNMSVSSMEYIPEG | - | 0.1942 | TP | certain | experimental | 55 | 23 | 73 | 20 | 72 | 9 | | 25485581 | - | - |
| SMAD2 (Q15796) | Homo sapiens | S245 | NQSMDTGSPAELSPT | 0.477 | 0.7369 | TP | certain | experimental | 23 | 72 | 9 | | 20659902 | - | - |
| SMAD3 (P84022) | Homo sapiens | S204 | NHSMDAGSPNLSPNP | 0.185 | 0.805 | TP | certain | experimental | 23 | 72 | 9 | | 20659902 | - | - |
| SMAD4 (Q13485) | Homo sapiens | S343 | GETFKVPSSCPIVTV | 0.675 | 0.2436 | TP | certain | experimental | 23 | 72 | 9 | | 20659902 | - | - |
| MAP3K5 (Q99683) | Homo sapiens | T838 | GINPCTETFTGTLQY | 0.596 | 0.2328 | TP | certain | experimental | 72 | 9 | 55 | | 18948261 | - | - |
| SMAD6 (O43541) | Homo sapiens | T176 | EQELKTVTYSLLKRL | 0.497 | 0.247 | TP | certain | experimental | 72 | 9 | | 20659902 | - | - |
| SMAD7 (O15105) | Homo sapiens | T96 | EADLKALTHSVLKKL | 0.217 | 0.4619 | TP | certain | experimental | 23 | 72 | 9 | | 20659902 | - | - |
| PDPK1 (O15530) | Homo sapiens | T354 | WENLHQQTPPKLTAY | 0.619 | 0.3321 | TP | certain | experimental | 72 | 55 | 9 | | 22544756 | - | - |
Help Instructions
- Hovering on the "*" in "Substrate" column will display the text if there is a note by the annotator for the given site.
- The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
- The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
- The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
- In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
- Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)