CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| MAPKAPK2 | MAP kinase-activated protein kinase 2 | P49137 | TH | EEF2K | TP53 | KRT18 | TH | TH | VIM | SRF | Hspb1 | Lsp1 | Zfp36 | LSP1 | Ddit3 | VIM | MAPKAPK2 | MDM2 | RCSD1 | Hnrnpa0 | Krt20 | HSPB1 | TSC2 | BAG2 | ALOX5 | YWHAZ | ARPC5 | CDC25B | HSF1 | LIMK1 | AKT1 | PLK1 | ZFP36L1 | Etv1 | RTN4 | TRIM29 | PIAS1 | AATF | AGO2 | PARN | CRYAB | Creb1 | CREB1 | Rps6ka1 | ATF1 | SHC1 | CDC25B | CDC25C | KRT20 | Pde4a | Creb1 | BCL2L1 | HNRNPA0 | Lpcat2 | Gys1 | Rps6ka3 | WNK4 | Rbm7 | MRTFA | Ripk1 | TH | Mrtfa | CEP131 | DDX5 | DAZL | RIPK1 | Hif3a | TRIM28 | PFKFB3 | BECN1 | ZFP36 | PDE4A | LSP1 | ETV1 | RPS6KA3 | E2F1 | RPS6KA1 | LPCAT2 | TAB3 | MYLK2 | RPS6KA1 | ZFP36 | DDIT3 | | | RBM7 | RIPK1 | PDE4A | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| FOS | Proto-oncogene c-Fos | P01100 | RPS6KA2 | RPS6KA1 | |
| IRS1 | Insulin receptor substrate 1 | P35568 | Sik2 | SIK1 | RPS6KA1 | PIM2 | PIM3 | PIM1 | SIK2 | |
| JUN | Transcription factor AP-1 | P05412 | PRKD1 | |
| MAPKAPK2 | MAP kinase-activated protein kinase 2 | P49137 | MAPKAPK2 | |
| PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Q14738 | CHEK1 | |
| SHC1 | SHC-transforming protein 1 | P29353 | Mapkapk2 | MAPKAPK2 | |
| STAT3 | Signal transducer and activator of transcription 3 | P40763 | RPS6KA3 | CAMK2G | Dapk3 | DAPK3 | |
| SYK | Tyrosine-protein kinase SYK | P43405 | CHEK1 | PRKAA1 | PRKD1 | |