CaMKinet | Result

Help Instruction

Double clicking on the substrate will redirect to the uniprot entry.
Clicking in the block having the substrate will zoom into its phophosites
Clicking the center of the circle will lead to zooming out.
Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
Clicking in the top right corner on the camara icon will download the image.

Sequence Logo

Graphics credits: Skylign

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CDC25B (P30305)	Homo sapiens	S323	QRLFRSPSMPCSVIR	0.939	0.2817	TP	certain	experimental	73 \| 8 \|	12400006	-	In vitro
MELK (Q14680)	Homo sapiens	S505	SPERRCRSVELDLNQ	0.990	0.4766	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S529	KGAKVFGSLERGLDK	0.947	0.4186	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S253	VDPKKRISMKNLLNH	0.090	0.1275	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S336	PVRLRLSSFSCGQAS	0.226	0.3631	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S343	SFSCGQASATPFTDI	0.353	0.3019	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S356	DIKSNNWSLEDVTAS	0.482	0.4149	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S391	GAATPRTSQFTKYWT	0.199	0.4476	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S407	SNGVESKSLTPALCR	0.414	0.4409	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S431	ENVYTPKSAVKNEEY	0.292	0.4017	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	T398	SQFTKYWTESNGVES	0.412	0.4441	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	T409	GVESKSLTPALCRTP	0.926	0.5493	TP	certain	experimental	214 \| 72 \|	16628004	-	In vivo
MELK (Q14680)	Homo sapiens	T494	TGTDKLMTGVISPER	0.292	0.5493	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	T539	RGLDKVITVLTRSKR	0.299	0.4441	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	T56	SDLPRIKTEIEALKN	0.221	0.2258	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S171	HLQTCCGSLAYAAPE	0.822	0.0443	TP	certain	experimental	62 \| 30 \|	16216881	-	-
CDC25B (P30305)	Homo sapiens	S169	VLRNITNSQAPDGRR	0.502	0.7951	TP	certain	experimental	72 \| 73 \| 55 \| 31 \| 143 \|	15908796	-	-
MELK (Q14680)	Homo sapiens	T167	NKDYHLQTCCGSLAY	0.843	0.1424	TP	certain	experimental	62 \| 30 \|	16216881	-	-
MELK (Q14680)	Homo sapiens	S405	TESNGVESKSLTPAL	0.693	0.3566	-	-	-	-	-	-	In vivo
MELK (Q14680)	Homo sapiens	T387	DLSTGAATPRTSQFT	0.181	0.3529	-	-	-	-	-	-	In vivo
EIF4B (P23588)	Homo sapiens	S406	RPRERHPSWRSEETQ	0.581	0.8462	-	-	-	-	-	-	in-vitro and in-vivo
EIF4B (P23588)	Homo sapiens	S422	RERSRTGSESSQTGT	0.591	0.9457	-	-	-	-	-	-	in-vitro
TP53 (P04637)	Homo sapiens	S15	PSVEPPLSQETFSDL	0.830	0.708	-	-	-	-	-	-	-
SMAD3 (P84022)	Homo sapiens	S204	NHSMDAGSPNLSPNP	0.185	0.805	-	-	-	-	-	-	-
SMAD4 (Q13485)	Homo sapiens	S343	GETFKVPSSCPIVTV	0.675	0.2436	-	-	-	-	-	-	-
SMAD2 (Q15796)	Homo sapiens	S245	NQSMDTGSPAELSPT	0.477	0.7369	-	-	-	-	-	-	-
SMAD7 (O15105)	Homo sapiens	T96	EADLKALTHSVLKKL	0.217	0.4619	-	-	-	-	-	-	-
PDPK1 (O15530)	Homo sapiens	T354	WENLHQQTPPKLTAY	0.619	0.3321	-	-	-	-	-	-	-
MAP3K5 (Q99683)	Homo sapiens	T838	GINPCTETFTGTLQY	0.596	0.2328	-	-	-	-	-	-	-

Help Instructions

Hovering on the "*" in "Substrate" column will display the text if there is a note by the annotator for the given site.
The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)