CaMKinet | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Parameter	Value
Gene	EGFR
Protein Name	EGFR_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	1956
UniProt ID	P00533
Enzyme Class	2.7.10.1
Molecular Weight	134277
Protein Length	1210
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Localization	Cell membrane; Isoform 2: Secreted.
Function (UniProt annotation)	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity).
Gene Ontology	GO:0000139; GO:0000165; GO:0001503; GO:0001618; GO:0001892; GO:0001934; GO:0001942; GO:0003682; GO:0003690; GO:0004709; GO:0004713; GO:0004714; GO:0004888; GO:0005006; GO:0005088; GO:0005178; GO:0005516; GO:0005524; GO:0005615; GO:0005634; GO:0005737; GO:0005768; GO:0005789; GO:0005886; GO:0005887; GO:0005925; GO:0006357; GO:0006412; GO:0006970; GO:0007165; GO:0007166; GO:0007173; GO:0007202; GO:0007435; GO:0007494; GO:0007611; GO:0007623; GO:0008283; GO:0008284; GO:0009925; GO:0009968; GO:0009986; GO:0010008; GO:0010750; GO:0010960; GO:0014066; GO:0016020; GO:0016101; GO:0016323; GO:0016324; GO:0018108; GO:0019899; GO:0019901; GO:0019903; GO:0021795; GO:0030139; GO:0030154; GO:0030307; GO:0030324; GO:0030335; GO:0030665; GO:0031625; GO:0031901; GO:0031965; GO:0032930; GO:0032991; GO:0033138; GO:0033590; GO:0033594; GO:0034614; GO:0038083; GO:0038128; GO:0042059; GO:0042060; GO:0042177; GO:0042327; GO:0042698; GO:0042743; GO:0042802; GO:0043006; GO:0043066; GO:0043235; GO:0043406; GO:0043586; GO:0045121; GO:0045202; GO:0045296; GO:0045739; GO:0045740; GO:0045746; GO:0045780; GO:0045893; GO:0045907; GO:0045930; GO:0045944; GO:0046328; GO:0046777; GO:0046934; GO:0046982; GO:0048143; GO:0048146; GO:0048408; GO:0048471; GO:0048546; GO:0048661; GO:0048812; GO:0050679; GO:0050729; GO:0050730; GO:0050999; GO:0051015; GO:0051205; GO:0051592; GO:0051897; GO:0051968; GO:0060571; GO:0061024; GO:0061029; GO:0070141; GO:0070372; GO:0070374; GO:0070435; GO:0071230; GO:0071260; GO:0071276; GO:0071364; GO:0071392; GO:0071549; GO:0090263; GO:0097421; GO:0097489; GO:0097755; GO:0098609; GO:1900020; GO:1901185; GO:1901224; GO:1902722; GO:1903078; GO:1903800; GO:1905208; GO:2000145

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	T678	RHIVRKRTLRRLLQE	0.415	0.3249	TP	certain	experimental	72 \| 9 \|	10523301	-	-
PRKD1 (Q15139)	Homo sapiens	T693	RELVEPLTPSGEAPN	0.275	0.4541	TP	certain	experimental	72 \| 9 \|	10523301	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S1070	DSFLQRYSSDPTGAL	0.5	0.5807	-	-	-	-	10347170	Non high throughput (10347170)	-
CAMK2A (Q9UQM7)	Homo sapiens	S1071	SFLQRYSSDPTGALT	0.5	0.6755	-	-	-	-	10347170	Non high throughput (10347170)	-
CAMK2A (Q9UQM7)	Homo sapiens	S1081	TGALTEDSIDDTFLP	0.5	0.7209	-	-	-	-	10347170	Non high throughput (10347170)	-
CAMK2A (Q9UQM7)	Homo sapiens	S1166	QKGSHQISLDNPDYQ	0.452	0.6089	-	-	-	-	10347170	Non high throughput (10347170)	-
CAMK2A (Q9UQM7)	Homo sapiens	S768	DEAYVMASVDNPHVC	0.574	0.0734	-	-	-	-	10347170	Non high throughput (10347170)	-
PRKAA1 (Q13131)	Homo sapiens	T892	SILHRIYTHQSDVWS	0.497	0.0473	-	-	-	-	-	-	in-vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04020	Calcium signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04144	Endocytosis
hsa04320	Dorso-ventral axis formation
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04540	Gap junction
hsa04810	Regulation of actin cytoskeleton
hsa04912	GnRH signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05223	Non-small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
arf6cyclingpathway	Arf6 signaling events
endothelinpathway	Endothelins
lysophospholipid_pathway	LPA receptor mediated events
ptp1bpathway	Signaling events mediated by PTP1B
syndecan_3_pathway	Syndecan-3-mediated signaling events
telomerasepathway	Regulation of Telomerase
txa2pathway	Thromboxane A2 receptor signaling