CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	RELA
Protein Name	TF65_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Protein Family	N/A
NCBI Gene ID	5970
UniProt ID	Q04206
Enzyme Class	-
Molecular Weight	60219
Protein Length	551
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression.
Gene Ontology	GO:0000122; GO:0000790; GO:0000977; GO:0000978; GO:0000980; GO:0000981; GO:0000983; GO:0001077; GO:0001078; GO:0001205; GO:0001889; GO:0001942; GO:0002223; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006117; GO:0006325; GO:0006355; GO:0006954; GO:0006968; GO:0007249; GO:0007568; GO:0008134; GO:0008284; GO:0009887; GO:0010033; GO:0010224; GO:0014040; GO:0016032; GO:0019221; GO:0019901; GO:0031293; GO:0031490; GO:0031625; GO:0032332; GO:0032481; GO:0032495; GO:0032570; GO:0032868; GO:0033209; GO:0033234; GO:0033590; GO:0033613; GO:0034097; GO:0035525; GO:0035729; GO:0035924; GO:0035994; GO:0038061; GO:0038095; GO:0042177; GO:0042301; GO:0042802; GO:0042803; GO:0042805; GO:0042826; GO:0043066; GO:0043123; GO:0043200; GO:0043278; GO:0043620; GO:0044212; GO:0044877; GO:0045084; GO:0045892; GO:0045893; GO:0045944; GO:0046627; GO:0046982; GO:0047485; GO:0050727; GO:0050852; GO:0050862; GO:0051059; GO:0051092; GO:0051591; GO:0051607; GO:0061614; GO:0070301; GO:0070431; GO:0070491; GO:0070498; GO:0070555; GO:0071222; GO:0071223; GO:0071224; GO:0071316; GO:0071347; GO:0071354; GO:0071356; GO:0071532; GO:0098978; GO:0099527; GO:1901222; GO:1901223; GO:1901224; GO:1901522; GO:1902894; GO:1902895; GO:1904385; GO:2000630; GO:2001237

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S276	SMQLRRPSDRELSEP	0.767	0.5382	TP	certain	experimental	72 \| 9 \| 55 \|	19911008	-	-
CAMK2G (Q13555)	Homo sapiens	S536	SGDEDFSSIADMDFS	0.319	0.2849	TP	certain	experimental	148 \| 72 \| 9 \| 55 \| 16 \| 31 \|	24248603	-	-
RPS6KA4 (O75676)	Homo sapiens	S276	SMQLRRPSDRELSEP	0.767	0.5382	-	-	-	-	-	-	In vivo
RPS6KA5 (O75582)	Homo sapiens	S276	SMQLRRPSDRELSEP	0.767	0.5382	-	-	-	-	12628924	Non high throughput (12628924)	In vitro and in vivo
CAMK4 (Q16566)	Homo sapiens	S536	SGDEDFSSIADMDFS	0.319	0.2849	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	T505	EAITRLVTGAQRPPD	0.384	0.8013	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04062	Chemokine signaling pathway
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05162	Measles
hsa05164	Influenza A
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer
hsa05215	Prostate cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
avb3_opn_pathway	Osteopontin-mediated events
bcr_5pathway	BCR signaling pathway
ceramidepathway	Ceramide signaling pathway
fcer1pathway	Fc-epsilon receptor I signaling in mast cells
hdac_classi_pathway	Signaling events mediated by HDAC Class I
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
il12_2pathway	IL12-mediated signaling events
il1pathway	IL1-mediated signaling events
il2_pi3kpathway	IL2 signaling events mediated by PI3K
il23pathway	IL23-mediated signaling events
lysophospholipid_pathway	LPA receptor mediated events
nfkappabatypicalpathway	Atypical NF-kappaB pathway
nfkappabcanonicalpathway	Canonical NF-kappaB pathway
tnfpathway	TNF receptor signaling pathway