| Gene |
FOS
|
| Protein Name |
FOS_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Proto-oncogene c-Fos (Cellular oncogene fos) (G0/G1 switch regulatory protein 7) |
| Protein Family |
BZIP family |
| NCBI Gene ID |
2353
|
| UniProt ID |
P01100
|
| Enzyme Class |
- |
| Molecular Weight |
40695 |
| Protein Length |
380 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. |
| Function (UniProt annotation) |
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Gene Ontology |
GO:0000978; GO:0000979; GO:0000981; GO:0001077; GO:0001102; GO:0001661; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005783; GO:0005829; GO:0006306; GO:0006357; GO:0006366; GO:0006954; GO:0007179; GO:0007399; GO:0007565; GO:0007568; GO:0008134; GO:0009409; GO:0009416; GO:0009629; GO:0009636; GO:0016020; GO:0019221; GO:0030431; GO:0031668; GO:0032496; GO:0032570; GO:0032870; GO:0032993; GO:0034614; GO:0035902; GO:0035914; GO:0035976; GO:0035994; GO:0038095; GO:0043005; GO:0044212; GO:0045672; GO:0045893; GO:0045944; GO:0046982; GO:0051090; GO:0051412; GO:0051591; GO:0060395; GO:0070412; GO:0071276; GO:0071277; GO:1901216; GO:1902895 |
