| Gene |
JUN
|
| Protein Name |
JUN_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) |
| Protein Family |
BZIP family |
| NCBI Gene ID |
3725
|
| UniProt ID |
P05412
|
| Enzyme Class |
- |
| Molecular Weight |
35676 |
| Protein Length |
331 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| Gene Ontology |
GO:0000122; GO:0000228; GO:0000790; GO:0000978; GO:0000980; GO:0000981; GO:0000982; GO:0001077; GO:0001102; GO:0001228; GO:0001525; GO:0001774; GO:0001836; GO:0001889; GO:0001938; GO:0003151; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0003713; GO:0003723; GO:0005096; GO:0005634; GO:0005654; GO:0005667; GO:0005719; GO:0005829; GO:0006366; GO:0007179; GO:0007265; GO:0007568; GO:0007612; GO:0007623; GO:0008134; GO:0008285; GO:0009314; GO:0009612; GO:0010033; GO:0010634; GO:0017053; GO:0019899; GO:0030224; GO:0031103; GO:0031625; GO:0031953; GO:0032496; GO:0032870; GO:0034097; GO:0034614; GO:0035026; GO:0035497; GO:0035976; GO:0035994; GO:0038095; GO:0042493; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0043392; GO:0043524; GO:0043525; GO:0043922; GO:0043923; GO:0044212; GO:0045597; GO:0045657; GO:0045740; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048146; GO:0051090; GO:0051365; GO:0051591; GO:0051726; GO:0051899; GO:0060395; GO:0061029; GO:0070374; GO:0070412; GO:0071276; GO:0071277; GO:0071837; GO:1902895; GO:1904707; GO:1990441; GO:2000144 |
