Help Instruction
- Double clicking on the substrate will redirect to the uniprot entry.
- Clicking in the block having the substrate will zoom into its phophosites
- Clicking the center of the circle will lead to zooming out.
- Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
- The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
- Clicking in the top right corner on the camara icon will download the image.
| Substrate | Organism | PSite | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crtc2 (Q3U182) | Mus musculus | S171 | SALNRTSSDSALHTS | - | 0.6576 | TP | certain | experimental | 23 | 72 | 73 | 8 | | 15454081 | - |
|
| HDAC4 (P56524) | Homo sapiens | S246 | FPLRKTASEPNLKLR | 0.871 | 0.6183 | TP | certain | experimental | 72 | 73 | 74 | 55 | | 23393134 | - | - |
| HDAC5 (Q9UQL6) | Homo sapiens | S259 | FPLRKTASEPNLKVR | 0.835 | 0.6712 | TP | certain | experimental | 72 | 73 | 74 | 55 | | 23393134 | - | - |
| VCP (P55072) | Homo sapiens | S770 | QQSRGFGSFRFPSGN | 0.013 | 0.6269 | TP | certain | experimental | 23 | 72 | 9 | 30 | 3 | 16 | | 24129571 | - | - |
| CEP250 * (Q9BV73 ) | Homo sapiens | S2392 | AGLHHSLSHSLLAVA | 0.829 | 0.5098 | TP | certain | experimental | 74 | 55 | 72 | 31 | | 20708153 | - | - |
| AKT1 (P31749) | Homo sapiens | S473 | RPHFPQFSYSASGTA | 0.952 | 0.5342 | TP | likely | experimental | 140 | | 20708153 | - | - |
| Irs1 (P35570) | Rattus norvegicus | S789 | QHLRLSSSSGRLRYT | - | 0.7209 | - | - | - | - | - | - |
|
| CEP250 (Q9BV73) | Homo sapiens | S2394 | LHHSLSHSLLAVAQA | 0.827 | 0.4901 | - | - | - | - | - | - |
|
| PIK3R1 (P27986) | Homo sapiens | S154 | STLYRTQSSSNLAEL | 0.197 | 0.2817 | - | - | - | - | - | - |
|
| SIK2 (Q9H0K1) | Homo sapiens | S90 | YQVMETKSMLYLVTE | 0.001 | 0.0327 | - | - | - | - | - | - |
|
| CDK5R1 (Q15078) | Homo sapiens | S91 | ENLKKSLSCANLSTF | 0.448 | 0.3631 | - | - | - | - | - | - |
|
| Crtc3 (Q91X84) | Mus musculus | S329 | SGLQSSRSNPSIQAT | - | 0.7163 | - | - | - | - | - | - |
|
| Crtc3 (Q91X84) | Mus musculus | S162 | SALNRTNSDSALHTS | - | 0.6269 | - | - | - | - | - | - |
|
| Crtc3 (Q91X84) | Mus musculus | S370 | SLRLFSLSNPSLSTT | - | 0.4901 | - | - | - | - | - | - |
|
| PIK3R1 (P27986) | Homo sapiens | S541 | RISEIIDSRRRLEED | 0.765 | 0.3631 | - | - | - | - | - | - |
|
| SIK2 (Q9H0K1) | Homo sapiens | S343 | RLKSHRSSFPVEQRL | 0.658 | 0.3872 | - | - | - | - | - | - |
|
| SIK2 (Q9H0K1) | Homo sapiens | S358 | DGRQRRPSTIAEQTV | 0.953 | 0.6136 | - | - | - | - | - | - |
|
| Crtc3 (Q91X84) | Mus musculus | S62 | LTQYHGGSLPNVSQL | - | 0.6089 | - | - | - | - | - | - |
|
| IRS1 (P35568) | Homo sapiens | S794 | QHLRLSTSSGRLLYA | 0.309 | 0.5854 | - | - | - | - | - | - | - |
| CRTC2 (Q53ET0) | Homo sapiens | S171 | SALNRTSSDSALHTS | 0.886 | 0.6531 | - | - | - | - | - | - | - |
| CRTC1 (Q6UUV9) | Homo sapiens | S151 | TSWRRTNSDSALHQS | 0.759 | 0.7547 | - | - | - | - | - | - | - |
| IRS1 (A0A024R499) | Homo sapiens | S794 | QHLRLSTSSGRLLYA | - | 0.5854 | - | - | - | - | - | - | - |
| CRTC3 (Q6UUV7) | Homo sapiens | S329 | SGLQSSRSNPSIQAT | 0.525 | 0.7415 | - | - | - | - | - | - | - |
| CRTC3 (Q6UUV7) | Homo sapiens | S162 | SALNRTNSDSALHTS | 0.890 | 0.6227 | - | - | - | - | - | - | - |
| CRTC3 (Q6UUV7) | Homo sapiens | S370 | SLRLFSLSNPSLSTT | 0.898 | 0.5055 | - | - | - | - | - | - | - |
| CRTC3 (Q6UUV7) | Homo sapiens | S62 | LTQYHGGSLPNVSQL | 0.771 | 0.5807 | - | - | - | - | - | - | - |
Help Instructions
- Hovering on the "*" in "Substrate" column will display the text if there is a note by the annotator for the given site.
- The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
- The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
- The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
- In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
- Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)