CHEK2 | Serine/threonine-protein kinase Chk2
 

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Substrate Organism PSite Sequence(+/-7) Conservation Disorder Curator Assessment Reliability Evidence Class Evidence Logic PubMed Phospho-ELM PhosphoSite-Plus
E2F3 (O00716-1) Homo sapiens S124 PALGRGGSGGGGGPP 0.130 0.9106 TP certain experimental 72 | 9 | 73 | 55 | 19917728 - -
CDC25A (P30304) Homo sapiens S124 PALKRSHSDSLDHDI 0.462 0.4476 - - - - - Non high throughput (11298456) In vitro and in vivo
CHEK2 (O96017) Homo sapiens T383 GETSLMRTLCGTPTY 0.910 0.1162 - - - - - Non high throughput (11390408) In vitro and in vivo
CHEK2 (O96017) Homo sapiens T387 LMRTLCGTPTYLAPE 0.857 0.1115 - - - - - Non high throughput (11390408) In vitro and in vivo
CHEK2 (O96017) Homo sapiens T68 SSLETVSTQELYSIP 0.781 0.5577 - - - - - Non high throughput (11901158) In vitro and in vivo
CDC25A (P30304) Homo sapiens S178 LFTQRQNSAPARMLS 0.959 0.6755 - - - - - Non high throughput (12676583) In vitro
CDC25A (P30304) Homo sapiens S279 VLKRPERSQEESPPG 0.549 0.8872 - - - - - Non high throughput (12676583) In vitro
CDC25A (P30304) Homo sapiens S293 GSTKRRKSMSGASPK 0.631 0.8713 - - - - - Non high throughput (12676583) In vitro
E2F1 (Q01094) Homo sapiens S364 PLLSRMGSLRAPVDE 0.364 0.6322 - - - - - Non high throughput (12717439) In vitro and in vivo
CHEK2 (O96017) Homo sapiens S516 PQVLAQPSTSRKRPR 0.537 0.6661 - - - - - Non high throughput (12805407) In vitro and in vivo
(P79923) Xenopus laevis S137 PAFKRNLSYSLECEV - 0.2436 - - - - - Non high throughput (15272308) -
(P79923) Xenopus laevis S190 GLVQRQKSAPACMLS - 0.5665 - - - - - Non high throughput (15272308) -
(P79923) Xenopus laevis S295 EKSKRRKSMSEIVNE - 0.6375 - - - - - Non high throughput (15272308) -
Cds1 (Q98TW0) Xenopus laevis T355 GETSLMRTLCGTPTY - 0.1206 - - - - - Non high throughput (15509799) -
Cds1 (Q98TW0) Xenopus laevis T359 LMRTLCGTPTYLAPE - 0.1791 - - - - - Non high throughput (15509799) -
TP53 (P04637) Homo sapiens S20 PLSQETFSDLWKLLP 0.567 0.6183 - - - - - Non high throughput (17339337) In vitro and in vivo
CDC25C (P30307) Homo sapiens S216 SGLYRSPSMPENLNR 0.868 0.6136 - - - - - Non high throughput (10744722, 9836640) In vitro
BRCA1 (P38398) Homo sapiens S988 PPLFPIKSFVKTKCK 0.798 0.2645 - - - - - Non high throughput (12111733, 14701743) In vitro and in vivo
XRCC1 (P18887) Homo sapiens T284 APTRTPATAPVPARA 0.433 0.8343 - - - - - - In vitro and in vivo
E2F3 (O00716) Homo sapiens S124 PALGRGGSGGGGGPP 0.130 0.9106 - - - - - - In vitro
MDM4 (O15151) Homo sapiens S342 SKLTHSLSTSDITAI 0.727 0.4292 - - - - - - In vitro and in vivo
MDM4 (O15151) Homo sapiens S367 PDCRRTISAPVVRPK 0.922 0.433 - - - - - - In vitro and in vivo
REV3L (O60673) Homo sapiens S1075 ENIKRTLSFRKKRSH 0.283 0.5254 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S120 YWFGRDKSCEYCFDE 0.327 0.1702 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S140 TDKYRTYSKKHFRIF 0.969 0.2034 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S19 SHGSSACSQPHGSVT 0.500 0.7982 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S260 KRKFAIGSAREADPA 0.148 0.1184 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S33 TQSQGSSSQSQGISS 0.500 0.7672 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S35 SQGSSSQSQGISSSS 0.500 0.7595 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens S379 SKILGETSLMRTLCG 0.459 0.1501 - - - - - - In vitro and in vivo
CHEK2 (O96017) Homo sapiens S435 SEHRTQVSLKDQITS 0.355 0.4292 - - - - - - In vitro
MBP (P02687) Bos taurus S150 HDAQGTLSKIFKLGG - 0.6136 - - - - - - In vitro
MBP (P02687) Bos taurus S17 SKYLASASTMDHARH - 0.5901 - - - - - - In vitro
TP53 (P04637) Homo sapiens S15 PSVEPPLSQETFSDL 0.830 0.708 - - - - - - In vitro
TP53 (P04637) Homo sapiens S366 PGGSRAHSSHLKSKK 0.367 0.9081 - - - - - - In vitro and in vivo
TP53 (P04637) Homo sapiens S37 NVLSPLPSQAMDDLM 0.107 0.708 - - - - - - In vitro
TP53 (P04637) Homo sapiens S378 SKKGQSTSRHKKLMF 0.826 0.7881 - - - - - - In vitro
RB1 (P06400) Homo sapiens S612 MYLSPVRSPKKKGST 0.442 0.433 - - - - - - In vitro and in vivo
MAPT (P10636-8) Homo sapiens S262 NVKSKIGSTENLKHQ 0.606 0.8125 - - - - - - In vitro and in vivo
HIST1H1C (P16403) Homo sapiens S36 GGTPRKASGPPVSEL 0.768 0.7415 - - - - - - In vitro
HIST1H1C (P16403) Homo sapiens S55 VAASKERSGVSLAAL 0.198 0.5296 - - - - - - In vitro
HIST1H1C (P16403) Homo sapiens S89 LGLKSLVSKGTLVQT 0.092 0.5017 - - - - - - In vitro
XRCC1 (P18887) Homo sapiens S184 EEDESANSLRPGALF 0.514 0.562 - - - - - - In vitro
XRCC1 (P18887) Homo sapiens S210 ASDPAGPSYAAATLQ 0.903 0.725 - - - - - - In vitro
PML (P29590-3) Homo sapiens S117 ESLQRRLSVYRQIVD 0.681 0.1373 - - - - - - In vitro and in vivo
VHL (P40337) Homo sapiens S111 GTGRRIHSYRGHLWL 0.156 0.3249 - - - - - - In vitro and in vivo
FOXM1 (Q08050-2) Homo sapiens S361 PLLPRVSSYLVPIQF 0.213 0.1671 - - - - - - In vitro and in vivo
TRIM28 (Q13263) Homo sapiens S473 SGVKRSRSGEGEVSG 0.459 0.7163 - - - - - - In vivo
ELAVL1 (Q15717) Homo sapiens S100 VSYARPSSEVIKDAN 0.601 0.1914 - - - - - - In vitro
ELAVL1 (Q15717) Homo sapiens S88 LNGLRLQSKTIKVSY 0.093 0.2918 - - - - - - In vitro
LATS2 (Q9NRM7) Homo sapiens S172 TPVTRRPSFEGTGDS 0.526 0.6183 - - - - - - In vitro
LATS2 (Q9NRM7) Homo sapiens S380 ATLARRDSLQKPGLE 0.706 0.7547 - - - - - - In vitro
LATS2 (Q9NRM7) Homo sapiens S408 PVPSRTNSFNSHQPR 0.893 0.9013 - - - - - - In vitro
LATS2 (Q9NRM7) Homo sapiens S446 HILHPVKSVRVLRPE 0.824 0.6183 - - - - - - In vitro
AATF (Q9NY61) Homo sapiens S143 SKKSRSHSAKTPGFS 0.131 0.6906 - - - - - - In vitro
AATF (Q9NY61) Homo sapiens S477 ELIERKTSSLDPNDQ 0.237 0.4186 - - - - - - In vitro
AATF (Q9NY61) Homo sapiens S510 KKVDRKASKGRKLRF 0.618 0.3566 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens T225 DEYIMSKTLGSGACG 0.135 0.1611 - - - - - - In vitro
CHEK2 (O96017) Homo sapiens T432 PPFSEHRTQVSLKDQ 0.203 0.4292 - - - - - - In vitro
MBP (P02687) Bos taurus T148 KGHDAQGTLSKIFKL - 0.6183 - - - - - - In vitro
MBP (P02687) Bos taurus T18 KYLASASTMDHARHG - 0.6322 - - - - - - In vitro
MBP (P02687) Bos taurus T33 FLPRHRDTGILDSLG - 0.4619 - - - - - - In vitro
MBP (P02687) Bos taurus T64 DGHHAARTTHYGSLP - 0.8125 - - - - - - In vitro
TP53 (P04637) Homo sapiens T18 EPPLSQETFSDLWKL 0.691 0.6183 - - - - - - In vitro
HIST1H1C (P16403) Homo sapiens T167 KPAAATVTKKVAKSP 0.099 0.7629 - - - - - - In vitro
HIST1H1C (P16403) Homo sapiens T92 KSLVSKGTLVQTKGT 0.371 0.5139 - - - - - - In vitro
TTK (P33981) Homo sapiens T288 SPDCDVKTDDSVVPC 0.231 0.3392 - - - - - - In vitro and in vivo
ELAVL1 (Q15717) Homo sapiens T118 SGLPRTMTQKDVEDM 0.405 0.3149 - - - - - - In vitro
SIAH2 (O43255) Homo sapiens S68 GGGAGPVSPQHHELT 0.066 0.6136 - - - - - - in-vivo
BAIAP2L1 (Q9UHR4) Homo sapiens S331 PSLQRSVSVATGLNM 0.970 0.5951 - - - - - - in-vitro
PSME3 (P61289) Homo sapiens S247 EKIKRPRSSNAETLY 0.675 0.3948 - - - - - - in-vivo
CDK11B (P21127) Homo sapiens S752 QRVKRGTSPRPPEGG 0.705 0.8085 - - - - - - in-vivo
SIAH2 (O43255) Homo sapiens S28 PQPQHTPSPAAPPAA 0.500 0.8741 - - - - - - in-vitro and in-vivo
SIAH2 (O43255) Homo sapiens T26 PPPQPQHTPSPAAPP 0.500 0.9168 - - - - - - in-vivo
SIAH2 (O43255) Homo sapiens T119 PTCRGALTPSIRNLA 0.052 0.0967 - - - - - - in-vivo
BLM (P54132) Homo sapiens T182 SHFVRVSTAQKSKKG 0.470 0.708 - - - - - - in-vitro and in-vivo
BDNF (P23560) Homo sapiens T62 GLTSLADTFEHVIEE 0.708 0.3019 - - - - - - in-vivo
MBP (P02686-3) Homo sapiens S178 VDAQGTLSKIFKLGG 0.870 0.4619 - - - - - - -
CHEK2 (O96017-12) Homo sapiens S487 PQVLAQPSTSRKRPR 0.351 0.6661 - - - - - - -
CHEK2 (O96017-9) Homo sapiens S559 PQVLAQPSTSRKRPR - 0.6661 - - - - - - -
PML (P29590) Homo sapiens S117 ESLQRRLSVYRQIVD 0.681 0.1373 - - - - - - -
FOXM1 (Q08050) Homo sapiens S376 PLLPRVSSYLVPIQF 0.844 0.2129 - - - - - - -
CDK11A (Q9UQ88) Homo sapiens S740 QRVKRGTSPRPPEGG 0.835 0.8013 - - - - - - -
CDC25A (P30304) Homo sapiens S298 RKSMSGASPKESTNP 0.371 0.8375 - - - - - - -
CHEK2 (O96017-4) Homo sapiens T292 GETSLMRTLCGTPTY 0.246 0.1162 - - - - - - -
CHEK2 (O96017-12) Homo sapiens T68 SSLETVSTQELYSIP 0.781 0.5577 - - - - - - -
BRCA2 (P51587) Homo sapiens T3387 LRLKRRCTTSLIKEQ 0.831 0.4119 - - - - - - -
MBP (P02686) Homo sapiens T21 KASTNSETNRGESEK 0.500 0.9168 - - - - - - -

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