CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| MYLK | Myosin light chain kinase, smooth muscle; | Q15746 | MYL9 | MYL12B | CALD1 | Myl12b | MYL2 | CALD1 | MYLK | CALD1 | |
| MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle; | Q9H1R3 | MYL9 | MYL12A | MYL12B | MEF2C | |
| MYLK3 | Myosin light chain kinase 3; | Q32MK0 | Ppp1r2 | PPP1R2B | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| MYLK | Myosin light chain kinase, smooth muscle; | Q15746 | MYLK | |
| MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle; | Q9H1R3 | MAPKAPK2 | |
| AKT1 | RAC-alpha serine/threonine-protein kinase; | P31749 | MAPKAPK2 | SIK2 | CAMKK2 | PRKD1 | |
| BAD | Bcl2-associated agonist of cell death; | Q92934 | PIM1 | PIM2 | PIM3 | CAMK2G | RPS6KA2 | RPS6KA1 | CHEK1 | PRKD1 | RPS6KA3 | |
| CTNNB1 | Catenin beta-1; | P35222 | PRKD1 | CAMK2A | PRKAA2 | |
| EGFR | Epidermal growth factor receptor; | P00533 | PRKD1 | CAMK2A | PRKAA1 | |
| ELK1 | ETS domain-containing protein Elk-1; | P19419 | RPS6KA5 | |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2; | P04626 | CAMK2A | PRKAA1 | |
| FLNA | Filamin-A; | P21333 | CAMK2A | CAMK2B | CAMK2D | CAMK2G | RPS6KA1 | |
| GSK3B | Glycogen synthase kinase-3 beta; | P49841 | RPS6KA3 | CAMK2B | PRKD3 | RPS6KA1 | STK11 | |
| ITGB1 | Integrin beta-1; | P05556 | CAMK2A | |
| ITGB4 | Integrin beta-4; | P16144 | RPS6KA1 | |
| JUN | Transcription factor AP-1; | P05412 | PRKD1 | |
| MYL12A | Myosin regulatory light chain 12A; | P19105 | MYLK2 | DAPK1 | CAMK1 | CAMK4 | |
| MYL12B | Myosin regulatory light chain 12B; | O14950 | MYLK | DAPK1 | Dapk1 | MYLK2 | DAPK3 | |
| MYL9 | Myosin regulatory light polypeptide 9; | P24844 | MYLK | DAPK3 | Camk1 | MYLK2 | DAPK1 | DAPK2 | CAMK1 | |
| PAK1 | Serine/threonine-protein kinase PAK 1; | Q13153 | BRSK2 | STK11 | |
| PPP1R12A | Protein phosphatase 1 regulatory subunit 12A; | O14974 | NUAK1 | DAPK3 | |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; | P60484 | STK11 | |
| SHC1 | SHC-transforming protein 1; | P29353 | Mapkapk2 | MAPKAPK2 | |
| VASP | Vasodilator-stimulated phosphoprotein; | P50552 | PRKAA1 | PRKD1 | PRKD2 | RPS6KA1 | |