CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| PIM1 | Serine/threonine-protein kinase pim-1; | P11309 | FOXO3 | MARK3 | MDM2 | POU5F1 | MAP3K5 | EIF4B | CDKN1A | FLT3 | LANA1 | RELA | Bad | CHEK1 | RUNX3 | HIST1H3A | Myc | | CDC25A | CXCR4 | Cxcr4 | SKP2 | CDKN1B | ABCG2 | UHRF1 | BAD | IRS1 | IRS2 | HBP1 | NKX3-1 | Notch1 | AR | FOXP3 | PIM1 | FOXO1 | MYC | PIM1 | RP9 | | CDC25A | NOTCH1 | MARK3 | AKT1S1 | |
| PIM2 | Serine/threonine-protein kinase pim-2; | Q9P1W9 | CDKN1A | Eif4b | Bad | CHEK1 | TSC2 | Myc | EIF4B | | CDKN1B | PKM | Foxp3 | Notch1 | IRS1 | MYC | MAP3K8 | MDM2 | EIF4EBP1 | BAD | PIM2 | | NOTCH1 | | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| PIM1 | Serine/threonine-protein kinase pim-1; | P11309 | PIM1 | |
| PIM2 | Serine/threonine-protein kinase pim-2; | Q9P1W9 | PIM2 | |
| AKT1 | RAC-alpha serine/threonine-protein kinase; | P31749 | MAPKAPK2 | SIK2 | CAMKK2 | PRKD1 | |
| BAD | Bcl2-associated agonist of cell death; | Q92934 | PIM1 | PIM2 | PIM3 | CAMK2G | RPS6KA2 | RPS6KA1 | CHEK1 | PRKD1 | RPS6KA3 | |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta; | O14920 | PRKAA2 | |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit; | P19838 | CHEK1 | |
| PML | Protein PML; | P29590 | CHEK2 | |
| RELA | Transcription factor p65; | Q04206 | RPS6KA4 | PIM1 | CAMK2G | RPS6KA5 | CAMK4 | CHEK1 | |
| STAT3 | Signal transducer and activator of transcription 3; | P40763 | RPS6KA3 | CAMK2G | Dapk3 | DAPK3 | |