PID pathway - IL2-mediated signaling events

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
FOS	Proto-oncogene c-Fos;	P01100	RPS6KA2 \| RPS6KA1 \|
IRS1	Insulin receptor substrate 1;	P35568	Sik2 \| PIM1 \| PIM2 \| PIM3 \| SIK1 \| RPS6KA1 \| SIK2 \|
JUN	Transcription factor AP-1;	P05412	PRKD1 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;	Q14738	CHEK1 \|
SHC1	SHC-transforming protein 1;	P29353	Mapkapk2 \| MAPKAPK2 \|
STAT3	Signal transducer and activator of transcription 3;	P40763	RPS6KA3 \| CAMK2G \| Dapk3 \| DAPK3 \|
SYK	Tyrosine-protein kinase SYK;	P43405	CHEK1 \| PRKAA1 \| PRKD1 \|