PID pathway - Role of Calcineurin-dependent NFAT signaling in lymphocytes

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	EP300 \| Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Camk4 \| HDAC4 \| CREBBP \| Hspb1 \| MYL12A \| RELA \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|
PIM1	Serine/threonine-protein kinase pim-1;	P11309	FOXO3 \| MARK3 \| MDM2 \| POU5F1 \| MAP3K5 \| EIF4B \| CDKN1A \| FLT3 \| LANA1 \| RELA \| Bad \| CHEK1 \| RUNX3 \| HIST1H3A \| Myc \| \| CDC25A \| CXCR4 \| Cxcr4 \| SKP2 \| CDKN1B \| ABCG2 \| UHRF1 \| BAD \| IRS1 \| IRS2 \| HBP1 \| NKX3-1 \| Notch1 \| AR \| FOXP3 \| PIM1 \| FOXO1 \| MYC \| PIM1 \| RP9 \| \| CDC25A \| NOTCH1 \| MARK3 \| AKT1S1 \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	EP300 \| Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Camk4 \| HDAC4 \| CREBBP \| Hspb1 \| MYL12A \| RELA \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
PIM1	Serine/threonine-protein kinase pim-1;	P11309	PIM1 \|
BAD	Bcl2-associated agonist of cell death;	Q92934	PIM1 \| PIM2 \| PIM3 \| CAMK2G \| RPS6KA2 \| RPS6KA1 \| CHEK1 \| PRKD1 \| RPS6KA3 \|
BCL2L1	Bcl-2-like protein 1;	Q07817	MAPKAPK2 \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
CREBBP	CREB-binding protein;	Q92793	CAMK4 \|
EP300	Histone acetyltransferase p300;	Q09472	Camk4 \| CAMK4 \| CAMK1 \| PRKAA1 \| Prkaa2 \| CAMK1D \| CAMK1G \|
GSK3B	Glycogen synthase kinase-3 beta;	P49841	RPS6KA3 \| CAMK2B \| PRKD3 \| RPS6KA1 \| STK11 \|
KPNA2	Importin subunit alpha-1;	P52292	PRKAA1 \| CHEK1 \|
YWHAZ	14-3-3 protein zeta/delta;	P63104	MAPKAPK2 \|