PID pathway - p38 signaling mediated by MAPKAP kinases

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
MAPKAPK3	MAP kinase-activated protein kinase 3;	Q16644	RTN4 \| RCSD1 \| TCF3 \| RTN4 \| BECN1 \| EEF2K \| HSPB1 \| KRT20 \| TAB3 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
CDC25B	M-phase inducer phosphatase 2;	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|
CREB1	Cyclic AMP-responsive element-binding protein 1;	P16220	RPS6KA4 \| MAPKAPK2 \| TSSK4 \| CAMK1D \| PRKD1 \| CAMK4 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| RPS6KA2 \| RPS6KA3 \| CAMK1 \| CAMK1G \| RPS6KA1 \| RPS6KA5 \|
ETV1	ETS translocation variant 1;	P50549	MAPKAPK2 \| RPS6KA1 \|
HSPB1	Heat shock protein beta-1;	P04792	MAPKAPK2 \| PRKD1 \| MAPKAPK5 \| MAPKAPK3 \| CAMK1 \| CAMK4 \|
LSP1	Lymphocyte-specific protein 1;	P33241	MAPKAPK2 \| Mapkapk2 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
SRF	Serum response factor;	P11831	MAPKAPK2 \| CAMK4 \| CAMK2A \| RPS6KA5 \|
TH	Tyrosine 3-monooxygenase;	P07101	MAPKAPK2 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| CAMK1 \| RPS6KA3 \|
TH	Tyrosine 3-monooxygenase;	P07101	MAPKAPK2 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| CAMK1 \| RPS6KA3 \|
TH	Tyrosine 3-monooxygenase;	P07101	MAPKAPK2 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| CAMK1 \| RPS6KA3 \|
TSC2	Tuberin;	P49815	MAPKAPK2 \| PIM2 \| BRSK2 \| RPS6KA1 \|
YWHAZ	14-3-3 protein zeta/delta;	P63104	MAPKAPK2 \|
CDC25B	M-phase inducer phosphatase 2;	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|