PID pathway - Signaling mediated by p38-alpha and p38-beta

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
MAPKAPK3	MAP kinase-activated protein kinase 3;	Q16644	RTN4 \| RCSD1 \| TCF3 \| RTN4 \| BECN1 \| EEF2K \| HSPB1 \| KRT20 \| TAB3 \|
MAPKAPK5	MAP kinase-activated protein kinase 5;	Q8IW41	SEPT8 \| PLA2G4A \| SEPT8 \| DNAJB1 \| FOXO3 \| TP53 \| HSPB1 \| TH \| KALRN \| DNAJB1 \| RHEB \| EEF2K \|
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1;	Q9BUB5	Eif4e \| SPRY2 \| SFPQ \| HNRNPA1 \| EIF4E \| Pla2g4a \| PNPLA8 \| PLA2G4A \| \| EIF4E \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RELA \| HIST1H2AG \| RPS6KA5 \| Rela \| HMGN1 \| TH \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A \| Hist1h3a \| H3F3A \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RELA \| HIST1H2AG \| RPS6KA5 \| Rela \| HMGN1 \| TH \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A \| Hist1h3a \| H3F3A \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RPS6KA5 \|
ATF1	Cyclic AMP-dependent transcription factor ATF-1;	P18846	MAPKAPK2 \| CAMK1 \| RPS6KA5 \|
CEBPB	CCAAT/enhancer-binding protein beta;	P17676	CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| RPS6KA1 \|
CREB1	Cyclic AMP-responsive element-binding protein 1;	P16220	RPS6KA4 \| MAPKAPK2 \| TSSK4 \| CAMK1D \| PRKD1 \| CAMK4 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| RPS6KA2 \| RPS6KA3 \| CAMK1 \| CAMK1G \| RPS6KA1 \| RPS6KA5 \|
CSNK2B	Casein kinase II subunit beta;	P67870	CHEK1 \|
EIF4E	Eukaryotic translation initiation factor 4E;	P06730	MKNK2 \| MKNK1 \|
ESR1	Estrogen receptor;	P03372	RPS6KA3 \| RPS6KA1 \|
HSPB1	Heat shock protein beta-1;	P04792	MAPKAPK2 \| PRKD1 \| MAPKAPK5 \| MAPKAPK3 \| CAMK1 \| CAMK4 \|
JUN	Transcription factor AP-1;	P05412	PRKD1 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
MEF2C	Myocyte-specific enhancer factor 2C;	Q06413	RPS6KA2 \| MYLK2 \|
PLA2G4A	Cytosolic phospholipase A2;	P47712	MAPKAPK5 \| Camk2a \| MKNK1 \| RPS6KA5 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RPS6KA5 \|
SLC9A1	Sodium/hydrogen exchanger 1;	P19634	RPS6KA1 \|
TP53	Cellular tumor antigen p53;	P04637	DAPK3 \| CHEK1 \| STK11 \| DAPK1 \| MAPKAPK2 \| NUAK1 \| MAPKAPK5 \| STK17A \| CHEK2 \| MELK \| PRKAA1 \| PRKAA2 \| SIK1 \|