KEGG pathway - Adipocytokine signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	Tbc1d4 \| IKBKB \| HDAC5 \| FOXO3 \| Vasp \| PLD1 \| HAS2 \| SIRT1 \| TP73 \| Tp53 \| Ppargc1a \| Kcnb1 \| ACACA \| PARP1 \| EEF2K \| DUSP1 \| Parp1 \| GLI1 \| TFAP2A \| Prkaa2 \| PPARGC1A \| PFKFB2 \| ULK1 \| NOS3 \| CTNNB1 \| ACACA \| ACACA \| CRTC2 \| TBC1D1 \| TP53 \| KCNB1 \| VASP \| TBC1D4 \| ACACB \| PARP1 \| FYN \| PPARGC1A \| \|
CAMKK1	Calcium/calmodulin-dependent protein kinase kinase 1;	Q8N5S9	CAMK4 \| CAMK1D \| Camk4 \| PRKAA1 \| CAMK1 \| BRSK1 \| Pacsin1 \|
CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2;	Q96RR4	Prkaa1 \| PRKAA1 \| Pacsin1 \| CAMKK2 \| AKT1 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	TP53 \| MBP \| Prkaa1 \| MELK \| STK11 \| BRSK1 \| PTEN \| MARK3 \| PRKAA2 \| SNRK \| BRSK1 \| BRSK2 \| MARK1 \| MARK2 \| MARK4 \| NUAK2 \| NUAK1 \| SIK1 \| SIK2 \| STRADA \| SMAD4 \| PAK1 \| SIK3 \| Stk11 \| SIK3 \| MARK3 \| Sik1 \| ETV4 \| GSK3B \| SIK1B \| \| STK11 \| SNRK \| MARK1 \|
CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2;	Q96RR4	Prkaa1 \| PRKAA1 \| Pacsin1 \| CAMKK2 \| AKT1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	TP53 \| MBP \| Prkaa1 \| MELK \| STK11 \| BRSK1 \| PTEN \| MARK3 \| PRKAA2 \| SNRK \| BRSK1 \| BRSK2 \| MARK1 \| MARK2 \| MARK4 \| NUAK2 \| NUAK1 \| SIK1 \| SIK2 \| STRADA \| SMAD4 \| PAK1 \| SIK3 \| Stk11 \| SIK3 \| MARK3 \| Sik1 \| ETV4 \| GSK3B \| SIK1B \| \| STK11 \| SNRK \| MARK1 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	STK11 \|
CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2;	Q96RR4	DAPK1 \| DAPK2 \| DAPK3 \| CAMKK2 \| STK17A \| STK17B \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	STK11 \|
ACACB	Acetyl-CoA carboxylase 2;	O00763	PRKAA1 \| PRKAA2 \|
AKT1	RAC-alpha serine/threonine-protein kinase;	P31749	MAPKAPK2 \| SIK2 \| CAMKK2 \| PRKD1 \|
CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2;	Q96RR4	DAPK1 \| DAPK2 \| DAPK3 \| CAMKK2 \| STK17A \| STK17B \|
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta;	O14920	PRKAA2 \|
IRS1	Insulin receptor substrate 1;	P35568	Sik2 \| PIM1 \| PIM2 \| PIM3 \| SIK1 \| RPS6KA1 \| SIK2 \|
NFKB1	Nuclear factor NF-kappa-B p105 subunit;	P19838	CHEK1 \|
NFKBIA	NF-kappa-B inhibitor alpha;	P25963	RPS6KA3 \| RPS6KA1 \|
NFKBIB	NF-kappa-B inhibitor beta;	Q15653	RPS6KA1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
PRKAB1	5'-AMP-activated protein kinase subunit beta-1;	Q9Y478	PRKAA1 \|
RELA	Transcription factor p65;	Q04206	RPS6KA4 \| PIM1 \| CAMK2G \| RPS6KA5 \| CAMK4 \| CHEK1 \|
STAT3	Signal transducer and activator of transcription 3;	P40763	RPS6KA3 \| CAMK2G \| Dapk3 \| DAPK3 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	STK11 \|