KEGG pathway - Insulin signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	Tbc1d4 \| IKBKB \| HDAC5 \| FOXO3 \| Vasp \| PLD1 \| HAS2 \| SIRT1 \| TP73 \| Tp53 \| Ppargc1a \| Kcnb1 \| ACACA \| PARP1 \| EEF2K \| DUSP1 \| Parp1 \| GLI1 \| TFAP2A \| Prkaa2 \| PPARGC1A \| PFKFB2 \| ULK1 \| NOS3 \| CTNNB1 \| ACACA \| ACACA \| CRTC2 \| TBC1D1 \| TP53 \| KCNB1 \| VASP \| TBC1D4 \| ACACB \| PARP1 \| FYN \| PPARGC1A \| \|
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1;	Q9BUB5	Eif4e \| SPRY2 \| SFPQ \| HNRNPA1 \| EIF4E \| Pla2g4a \| PNPLA8 \| PLA2G4A \| \| EIF4E \|
MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2;	Q9HBH9	SPRY2 \| SFPQ \| PLEC \| EIF4E \| HNRNPA1 \| ADRB2 \| CHRM2 \| MC4R \| CCR5 \| ADRA1B \|
PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform;	Q16816	GAP43 \| NRGN \| GAP43 \| MAPT \| MAPT \| MAPT \| NRGN \| PYGM \| PYGB \| PHKG1 \| PHKA1 \| TNNT3 \| TNNI3 \| TNNI2 \|
PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform;	P15735	PHKG1 \| PYGM \| PYGB \| PHKA1 \| MAPT \| TNNT3 \| TNNI3 \| TNNI2 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	STK11 \|
PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform;	Q16816	PHKG2 \| PHKG1 \|
ACACA	Acetyl-CoA carboxylase 1;	Q13085	PRKAA1 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| CAMK1D \| CAMK1G \| CAMK4 \| PRKAA2 \|
ACACB	Acetyl-CoA carboxylase 2;	O00763	PRKAA1 \| PRKAA2 \|
AKT1	RAC-alpha serine/threonine-protein kinase;	P31749	MAPKAPK2 \| SIK2 \| CAMKK2 \| PRKD1 \|
BAD	Bcl2-associated agonist of cell death;	Q92934	PIM1 \| PIM2 \| PIM3 \| CAMK2G \| RPS6KA2 \| RPS6KA1 \| CHEK1 \| PRKD1 \| RPS6KA3 \|
EIF4E	Eukaryotic translation initiation factor 4E;	P06730	MKNK2 \| MKNK1 \|
ELK1	ETS domain-containing protein Elk-1;	P19419	RPS6KA5 \|
GSK3B	Glycogen synthase kinase-3 beta;	P49841	RPS6KA3 \| CAMK2B \| PRKD3 \| RPS6KA1 \| STK11 \|
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta;	O14920	PRKAA2 \|
IRS1	Insulin receptor substrate 1;	P35568	Sik2 \| PIM1 \| PIM2 \| PIM3 \| SIK1 \| RPS6KA1 \| SIK2 \|
LIPE	Hormone-sensitive lipase;	Q05469	CAMK1 \| PRKAA1 \|
PPP1R3A	Protein phosphatase 1 regulatory subunit 3A;	Q16821	RPS6KA1 \| RPS6KA3 \|
PPP1R3C	Protein phosphatase 1 regulatory subunit 3C;	Q9UQK1	PRKAA1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
PRKAB1	5'-AMP-activated protein kinase subunit beta-1;	Q9Y478	PRKAA1 \|
RPS6	40S ribosomal protein S6;	P62753	RPS6KA3 \| DAPK1 \| PASK \| RPS6KA1 \|
RPTOR	Regulatory-associated protein of mTOR;	Q8N122	Prkaa1 \| Prkaa2 \| PRKAA1 \| RPS6KA1 \|
SHC1	SHC-transforming protein 1;	P29353	Mapkapk2 \| MAPKAPK2 \|
TSC2	Tuberin;	P49815	MAPKAPK2 \| PIM2 \| BRSK2 \| RPS6KA1 \|