KEGG pathway - MAPK signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
MAPKAPK3	MAP kinase-activated protein kinase 3;	Q16644	RTN4 \| RCSD1 \| TCF3 \| RTN4 \| BECN1 \| EEF2K \| HSPB1 \| KRT20 \| TAB3 \|
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1;	Q9BUB5	Eif4e \| SPRY2 \| SFPQ \| HNRNPA1 \| EIF4E \| Pla2g4a \| PNPLA8 \| PLA2G4A \| \| EIF4E \|
MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2;	Q9HBH9	SPRY2 \| SFPQ \| PLEC \| EIF4E \| HNRNPA1 \| ADRB2 \| CHRM2 \| MC4R \| CCR5 \| ADRA1B \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	PPP1R3A \| ESR2 \| CEBPB \| BAD \| ETV1 \| NFKBIB \| IRS1 \| EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| TSC2 \| Tsc2 \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2;	Q15349	BAD \| CREB1 \| RRN3 \| CDKN1B \| ATF4 \| Atf4 \| NFATC4 \| DAPK1 \| MEF2C \| FOS \| RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3;	P51812	Mybpc3 \| PFKFB2 \| CIC \| KCNK3 \| ESR1 \| EIF2S1 \| Nr4a1 \| Htr2a \| Creb1 \| ATF4 \| EIF2AK2 \| Cebpb \| NFKBIA \| HIST1H2BB \| STAT3 \| Gata4 \| CDKN1B \| GSK3A \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| PPP1R3A \| NFATC4 \| RRN3 \| CREB1 \| HMGN1 \| TH \| TH \| TH \| PFKFB2 \| Mybpc3 \| Rps6 \| HIST1H3A \| H3F3A \| PPP1R3A \| BAD \| RANBP3 \| MAP3K5 \| WWC1 \| TH \| TINF2 \| LCP1 \| TBX21 \| FGFR1 \| STMN1 \| EPHA2 \| SLC9A3 \| CASP8 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RELA \| HIST1H2AG \| RPS6KA5 \| Rela \| HMGN1 \| TH \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A \| Hist1h3a \| H3F3A \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|
MAPKAPK5	MAP kinase-activated protein kinase 5;	Q8IW41	SEPT8 \| PLA2G4A \| SEPT8 \| DNAJB1 \| FOXO3 \| TP53 \| HSPB1 \| TH \| KALRN \| DNAJB1 \| RHEB \| EEF2K \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	SRF \| HNRNPA0 \| TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| CREB1 \| AGO2 \| PARN \| CRYAB \| Creb1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	PPP1R3A \| ESR2 \| CEBPB \| BAD \| ETV1 \| NFKBIB \| IRS1 \| EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| TSC2 \| Tsc2 \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RELA \| HIST1H2AG \| RPS6KA5 \| Rela \| HMGN1 \| TH \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A \| Hist1h3a \| H3F3A \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	MAPKAPK2 \| RPS6KA1 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2;	Q15349	RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3;	P51812	MAPKAPK2 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RPS6KA5 \|
AKT1	RAC-alpha serine/threonine-protein kinase;	P31749	MAPKAPK2 \| SIK2 \| CAMKK2 \| PRKD1 \|
ATF4	Cyclic AMP-dependent transcription factor ATF-4;	P18848	RPS6KA3 \| RPS6KA2 \|
CACNA1C	Voltage-dependent L-type calcium channel subunit alpha-1C;	Q13936	CAMK2A \| PRKD1 \|
CDC25B	M-phase inducer phosphatase 2;	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|
EGFR	Epidermal growth factor receptor;	P00533	PRKD1 \| CAMK2A \| PRKAA1 \|
ELK1	ETS domain-containing protein Elk-1;	P19419	RPS6KA5 \|
FLNA	Filamin-A;	P21333	CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \| RPS6KA1 \|
FOS	Proto-oncogene c-Fos;	P01100	RPS6KA2 \| RPS6KA1 \|
HSPB1	Heat shock protein beta-1;	P04792	MAPKAPK2 \| PRKD1 \| MAPKAPK5 \| MAPKAPK3 \| CAMK1 \| CAMK4 \|
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta;	O14920	PRKAA2 \|
JUN	Transcription factor AP-1;	P05412	PRKD1 \|
MAP3K5	Mitogen-activated protein kinase kinase kinase 5;	Q99683	PIM1 \| Melk \| MELK \| PRKD1 \| RPS6KA3 \|
MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1;	Q92918	PRKD1 \|
MAPKAPK2	MAP kinase-activated protein kinase 2;	P49137	MAPKAPK2 \|
MAPT	Microtubule-associated protein tau;	P10636	MARK1 \| MARK4 \| BRSK1 \| BRSK2 \| PRKAA1 \| SIK1 \|
MEF2C	Myocyte-specific enhancer factor 2C;	Q06413	RPS6KA2 \| MYLK2 \|
NFATC4	Nuclear factor of activated T-cells, cytoplasmic 4;	Q14934	RPS6KA3 \| RPS6KA2 \|
NFKB1	Nuclear factor NF-kappa-B p105 subunit;	P19838	CHEK1 \|
PAK1	Serine/threonine-protein kinase PAK 1;	Q13153	BRSK2 \| STK11 \|
PLA2G4A	Cytosolic phospholipase A2;	P47712	MAPKAPK5 \| Camk2a \| MKNK1 \| RPS6KA5 \|
RELA	Transcription factor p65;	Q04206	RPS6KA4 \| PIM1 \| CAMK2G \| RPS6KA5 \| CAMK4 \| CHEK1 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	MAPKAPK2 \| RPS6KA1 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4;	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5;	O75582	RPS6KA5 \|
SRF	Serum response factor;	P11831	MAPKAPK2 \| CAMK4 \| CAMK2A \| RPS6KA5 \|
STMN1	Stathmin;	P16949	CAMK4 \| CAMK2A \| CAMK2B \| RPS6KA3 \|
TP53	Cellular tumor antigen p53;	P04637	DAPK3 \| CHEK1 \| STK11 \| DAPK1 \| MAPKAPK2 \| NUAK1 \| MAPKAPK5 \| STK17A \| CHEK2 \| MELK \| PRKAA1 \| PRKAA2 \| SIK1 \|
CDC25B	M-phase inducer phosphatase 2;	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|